We have used multilocus analysis to exclude the cystic fibrosis locus from six polymorphic DNA markers covering most of chromosome 19. A substantial increase in the confidence for exclusion was obtained using the computer programme LINKAGE compared to analysis of pairwise lod scores. A structured approach to the analysis of linkage to autosomal recessive inherited diseases where the biochemical defect is not known is described.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1049778 | PMC |
| http://dx.doi.org/10.1136/jmg.23.5.417 | DOI Listing |
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