AI Article Synopsis
- - The study evaluated the safety and effectiveness of penile-sparing surgery (PSS) in 13 patients who had local recurrence of penile cancer after prior surgeries (glansectomy or partial penectomy) from 1997 to 2022.
- - Most patients had glansectomy prior to PSS, with various surgical techniques utilized, and only one instance of a moderate complication was noted during treatment, which generally took place in an outpatient setting.
- - After a median follow-up of 41 months, local recurrence was seen in 23% of patients and was successfully treated with additional surgery, highlighting the need for further studies to refine patient selection for better oncological outcomes.
Article Abstract
We tested the feasibility and oncological outcomes after penile-sparing surgery (PSS) for local recurrent penile cancer after a previous glansectomy/partial penectomy. We retrospectively analysed 13 patients (1997-2022) with local recurrence of penile cancer after a previous glansectomy or partial penectomy. All patients underwent PSS: circumcision, excision, or laser ablation. First, technical feasibility, treatment setting, and complications (Clavien-Dindo) were recorded. Second, Kaplan-Meier plots depicted overall and local recurrences over time. Overall, 11 (84.5%) vs. 2 (15.5%) patients were previously treated with glansectomy vs. partial penectomy. The median (IQR) time to disease recurrence was 56 (13-88) months. Six (46%) vs. two (15.5%) vs. five (38.5%) patients were treated with, respectively, local excision vs. local excision + circumcision vs. laser ablation. All procedures, except one, were performed in an outpatient setting. Only one Clavien-Dindo 2 complication was recorded. The median follow-up time was 41 months. Overall, three (23%) vs. four (30.5%) patients experienced local vs. overall recurrence, respectively. All local recurrences were safely treated with salvage surgery. In conclusion, we reported the results of a preliminary analysis testing safety, feasibility, and early oncological outcomes of PSS procedures for patients with local recurrence after previous glansectomy or partial penectomy. Stronger oncological outcomes should be tested in other series to optimise patient selection.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10571586 | PMC |
| http://dx.doi.org/10.3390/cancers15194807 | DOI Listing |
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