Observations on the Clinical Features of the Wernicke-Korsakoff Syndrome.

J Clin Med

King's College London, Institute of Psychiatry, Psychology & Neuroscience, London SE5 8AF, UK.

Published: September 2023

This paper begins with a short case report of florid, spontaneous confabulation in a 61-year-old man with an alcohol-induced Wernicke-Korsakoff syndrome. His confabulation extended across episodic and personal semantic memory, as well as orientation in time and place, as measured on Dalla Barba's Confabulation Battery. Five other brief case summaries will then be presented, followed by a summary of the clinical, neurological, and background neuropsychological findings in three earlier series of Korsakoff patients. These observations will be considered in light of Wijnia's recent and my own, earlier reviews of the Korsakoff syndrome. Taken together, they indicate the need for a multi-faceted approach (clinical, neurological, neuropsychological, and neuroimaging) to the assessment and diagnosis of the disorder.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10573380PMC
http://dx.doi.org/10.3390/jcm12196310DOI Listing

Publication Analysis

Top Keywords

wernicke-korsakoff syndrome
8
clinical neurological
8
observations clinical
4
clinical features
4
features wernicke-korsakoff
4
syndrome paper
4
paper short
4
short case
4
case report
4
report florid
4

Similar Publications

We present a case of a male in his early 50s assessed in the emergency department with a seemingly clear alcohol history but with classic symptoms of Wernicke's encephalopathy (WE): disorientation, gait ataxia and vertical nystagmus. He also had significant bilateral hearing loss and profound anterograde amnesia. Neuroimaging revealed hallmark signs of WE, including symmetrical T2/fluid-attenuated inversion recovery hyperintensity in the medial thalami.

View Article and Find Full Text PDF

Objectives: Wernicke encephalopathy (WE) is an acute neuropsychiatric disorder caused by thiamine deficiency. The classical triad of symptoms for WE include mental status changes, ataxia, and ophthalmoplegia. In contrast, more uncommon symptoms include hallucinations.

View Article and Find Full Text PDF

Wernicke's encephalopathy, the acute phase of Wernicke-Korsakoff syndrome, is characterised as a triad of altered mental status, ocular signs and ataxia. Our patient presented with hyperemesis gravidarum, which is a rare aetiology of Wernicke's encephalopathy. The patient did not have any oculomotor abnormalities, which are more common and classically described in Wernicke's triad.

View Article and Find Full Text PDF
Article Synopsis
  • * This review examines the effectiveness of non-pharmacological interventions for apathy across different conditions similar to KS, including dementia, Parkinson's disease, schizophrenia, and traumatic brain injury, drawing on 22 systematic reviews and 32 empirical studies.
  • * Successful interventions for severely cognitively impaired individuals rely on external stimulation rather than intrinsic motivation, highlighting the need to tailor treatments to the individual's interests and assess the specific apathetic behaviors before starting any intervention.
View Article and Find Full Text PDF

Social norms in Korsakoff's syndrome and alcohol-related dementia.

J Clin Exp Neuropsychol

November 2024

Department of Neurology and Alzheimer Center Erasmus MC, Erasmus MC University Medical Center, Rotterdam, the Netherlands.

Article Synopsis
  • Social cognition is crucial for interpreting social information, and this study examined its impairment in individuals with Korsakoff's syndrome (KS) and alcohol-related dementia (ARD) compared to healthy controls.
  • The study included 30 KS patients, 10 ARD patients, and 74 matched controls, using the Social Norms Questionnaire to measure social cognition.
  • Results indicated that both KS and ARD patients struggled more with judging social norms than controls, with KS patients making significantly more judgment errors, highlighting the social behavior challenges faced by these patients.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!