In this study, the effects of heat treatment on the microstructure and strength (micro-hardness) of an aluminum-lithium (Al-Li) base alloy containing copper (Cu) and scandium (Sc) were investigated, with a view to enhancing the alloy performance for aerospace applications. The heat treatment conditions were investigated to understand the precipitation behavior and the mechanisms involved in strengthening. Aging was carried out at temperatures of 130 °C and 150 °C for aging times of 1 h, 2.5 h, 5 h, 10 h, 15 h, 25 h, 35 h, and 45 h at each temperature for Al-Li alloy and at 160 °C, 180 °C, and 200 °C for aging times of 5 h, 10 h, 15 h, 20 h, 25 h, and 30 h at each temperature for Al-Li-Cu and Al-Li-Cu-Sc alloys. The investigation revealed that both solution heat treatment and artificial aging had a notable impact on strengthening the hardness of the alloy. This effect was attributed to the characteristics of the precipitates, including their type, size, number density, and distribution. The addition of copper (Cu) and scandium (Sc) was observed to have an impact on grain size refinement, while Cu addition specifically affected the precipitation behavior of the alloy. It led to remarkable changes in the number density, size, and distribution of T1 (AlCuLi) and θ' (AlCu) phases. As a result, the hardness of the alloy was significantly improved after the addition of Cu and Sc, in comparison with the base Al-Li alloy. The best heat treatment process was determined as: 580 °C/1 h solution treatment +150 °C/45 h artificial aging for Al-Li alloy and 505 °C/5 h solution treatment +180 °C/20 h artificial aging for Al-Li-Cu and Al-Li-Cu-Sc alloys.
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http://dx.doi.org/10.3390/ma16196502 | DOI Listing |
Curr Pain Headache Rep
January 2025
Department of Physical Medicine & Rehabilitation, New York University Langone Health, New York, NY, USA.
Purpose Of Review: Chronic pain is highly prevalent and involves a complex interaction of sensory, emotional, and cognitive processes, significantly influenced by ambient temperature. Despite advances in pain management, many patients continue to experience inadequate pain relief. This review aims to consolidate and critically evaluate the current evidence on the impact of ambient temperature on chronic pain conditions such as fibromyalgia (FM), multiple sclerosis (MS), complex regional pain syndrome (CRPS), and osteoarthritis (OA).
View Article and Find Full Text PDFJ Public Health Manag Pract
January 2025
Department of Environmental Medicine and Public Health (Mr Bland, Dr Zajac, Ms Guel, Dr Pendley, Dr Galvez, Dr Sheffield), Icahn School of Medicine at Mount Sinai, New York, New York; Harvard Kenneth C. Griffin Graduate School of Arts and Sciences (Mr Wilson), Boston, Massachusetts; Environmental Research and Translation for Health (EaRTH) Center (Ms Charlesworth), University of California, San Francisco, California; Community Engagement Core, Environmental Health Sciences Center at Department of Environmental Medicine (Dr Korfmacher), University of Rochester Medical Center, Rochester, New York; Pediatric Environmental Health and Cincinnati Children's Hospital Medical Center (Dr Newman), Cincinnati, Ohio; Philadelphia Regional Center for Children's Environmental Health, Center of Excellence in Environmental Toxicology, Perelman School of Medicine (Dr Howarth), University of Pennsylvania, Philadelphia, Pennsylvania; and Division of Academic General Pediatrics, Children's Hospital at Montefiore (Dr Balk), Albert Einstein College of Medicine, Bronx, New York.
The integration of environmental health (EH) into routine clinical care for children is in its early stages. The vision of pediatric EH is that all clinicians caring for children are aware of and able to help connect families to needed resources to reduce harmful environmental exposures and increase health-enhancing ones. Environmental exposures include air pollution, substandard housing, lead, mercury, pesticides, consumer products chemicals, drinking water contaminants, industrial facility emissions and, increasingly, climate change-related extreme weather and heat events.
View Article and Find Full Text PDFSmall
January 2025
College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Provincial Key Laboratory of Clean Production of Fine Chemicals, Shandong Normal University, Jinan, 250014, P. R. China.
Cancer is one of the leading causes of death worldwide, posing a significant threat to human health. Although immunotherapy has shown promise in cancer treatment, its efficacy is often compromised by tumor immune evasion, which hinders treatment outcomes. Therefore, combining immunotherapy with other therapeutic approaches to enhance its effectiveness has become an increasingly accepted strategy in clinical practice.
View Article and Find Full Text PDFFront Vet Sci
January 2025
Research Group in Bioclimatology, Ethology and Animal Welfare (BioEt), Department of Animal Science, Federal University of Paraiba, Areia, Paraiba, Brazil.
Japanese quails () are sensitive to zinc (Zn) deficiency, a mineral essential for growth, development, and bone health. This study evaluated the effects of different levels of Zn in the diet on zootechnical performance, organ and carcass weight, and tibial breakage resistance in quails from 1 to 42 days of age. A 5 × 2 factorial design was used, consisting of five Zn levels (30, 60, 90, 120, and 150 mg/kg) and two thermal environments (thermal comfort and heat stress), with five replicates of 10 birds per treatment.
View Article and Find Full Text PDFFront Genome Ed
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State Key Laboratory of Animal Biotech Breeding, China Agricultural University, Beijing, China.
Primordial germ cells (PGCs) play a crucial role in transmitting genetic information to the next-generation. In chickens, genetically edited PGCs can be propagated and subsequently transplanted into recipient embryos to produce offspring with desired genetic traits. However, during early embryogenesis, the effects of external conditions on PGC migration through the vascular system to the gonads have yet to be explored, which may affect the efficiency of preparing gene-edited chickens.
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