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Cannabinoids for treating psychiatric disorders in youth: a systematic review of randomized controlled trials.
Child Adolesc Psychiatry Ment Health
December 2024
University Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.
Background: Cannabinoids have been of increasing interest mainly due to their putative efficacy in a wide array of psychiatric, psychosomatic, and neurological conditions.
Aims: This systematic review aims to synthesize results from randomized placebo-controlled trials regarding the efficacy and the dosage of cannabinoids as therapeutics in psychiatric disorders in children, adolescents, and young adults.
Methods: All publications up to June 30th, 2024, were included from PubMed and Embase.
["Pseudoneurotransmission" and gut microbiome - brain communication in neuropsychiatric disorders].
Psychiatriki
December 2024
Democritus University of Thrace, Alexandroupolis, Greece.
The gut microbiome, which comprises symbiotic bacteria colonizing the human digestive tract, undergoes dynamic changes during the lifespan, as evidenced by the fact that the number of species and the diversity of their composition decrease significantly with age. The aim of this review is to illuminate bilateral neuroimmunological pathways that determine the role of gut microbiome dysbiosis, not only as a cause but also as a byproduct of many neurodegenerative diseases of the CNS, such as Alzheimer's disease (AD) and Parkinson's disease (PD), but also in the frame of several behavioral and psychiatric pathological conditions such as depressive and anxiety disorders, schizophrenia, and autism spectrum disorder (ASD). Dysbiosis, in particular, reveals a model of "deceptive" mimicry of host molecules that might cause abnormal folding ("misfolding") and pathological aggregation of Aβ-peptide, leading to its dispersion through the gut-brain axis, precipitating microglia cell activation.
View Article and Find Full Text PDFSchizophrenia in children, adults and older people with intellectual disability compared with the general population: a Swedish register study (IDcare).
Gen Psychiatr
December 2024
Occupational and Environmental Medicine, Laboratory Medicine, Lund University, Lund, Sweden.
Background: The knowledge about the prevalence of schizophrenia among people with intellectual disabilities (ID) is sparse, particularly concerning the distribution in different age groups.
Aims: To investigate the prevalence of diagnoses in the schizophrenia spectrum among people with ID compared with the general population (gPop).
Methods: This was an 8-year longitudinal register study.
Neural circuits and therapeutic mechanisms of empathic pain.
Neuropharmacology
December 2024
Department of Anesthesiology and Perioperative Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China. Electronic address:
Empathy is the capacity to understand and share the experiences of others. This ability fosters connections between individuals, enriching the fabric of our shared world. One notable example is empathy for the pain of others.
View Article and Find Full Text PDFDelusion-proneness predicts COVID-19 vaccination behavior.
Front Psychiatry
November 2024
Centre for Psychiatry Research (CPF), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Introduction: Vaccination-related conspiracy ideation is related to reduced compliance with public health advice globally. Such beliefs have previously been linked to the delusion-proneness trait. However, it is not known how this extends to getting vaccinated.
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