Manipulating bosonic condensates with electric fields is very challenging as the electric fields do not directly interact with the neutral particles of the condensate. Here we demonstrate a simple electric method to tune the vorticity of exciton-polariton condensates in a strong coupling liquid crystal (LC) microcavity with CsPbBr_{3} microplates as active material at room temperature. In such a microcavity, the LC molecular director can be electrically modulated giving control over the polariton condensation in different modes. For isotropic nonresonant optical pumping we demonstrate the spontaneous formation of vortices with topological charges of +1, +2, -2, and -1. The topological vortex charge is controlled by a voltage in the range of 1 to 10 V applied to the microcavity sample. This control is achieved by the interplay of a built-in potential gradient, the anisotropy of the optically active perovskite microplates, and the electrically controllable LC molecular director in our system with intentionally broken rotational symmetry. Besides the fundamental interest in the achieved electric polariton vortex control at room temperature, our work paves the way to micron-sized emitters with electric control over the emitted light's phase profile and quantized orbital angular momentum for information processing and integration into photonic circuits.
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http://dx.doi.org/10.1103/PhysRevLett.131.136901 | DOI Listing |
J Fluoresc
January 2025
Department of Chemistry, Quaid-i-Azam University, Islamabad, 45320, Pakistan.
From synthesis to application, there are always certain interactions between the polar solvents and perovskite nanocrystals (NCs). To explain the effect of solvent polarity especially on the photoluminescence (PL) properties of NCs is highly desirable, especially for sensing applications. Herein We have synthesized the methylammonium lead mixed halides (MAPbClBr, where n = 0, 0.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Background: The detection and monitoring of Alzheimer's disease (AD) biomarkers in plasma are crucial for early diagnosis and prognosis. However, the stability of plasma AD biomarkers can be compromised by the degradation caused by endogenous proteases present in blood. The efficacy of protease inhibitors in mitigating this degradation is yet to be established.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden; UCL Institute of Neurology, Queen Square, London, United Kingdom.
Background: Recent advancements in sample collection and storage methods, as well as biomarker measurement technologies, have made it possible to determine highly accurate biomarkers for Alzheimer's disease (AD) in regular plasma samples collected by venipuncture or as dried plasma spots.
Methods: A novel ultrasensitive biomarker measurement method called NUcleic acid Linked Immuno-Sandwich Assay (NULISA), which improves the sensitivity of traditional proximity ligation assays to attomolar level, by suppressing assay background via a dual capture and release mechanism, was evaluated against Single molecule array (Simoa) technology for AD biomarker measurement. Dried plasma spots were evaluated in relation to regularly collected EDTA plasma samples.
Angew Chem Int Ed Engl
January 2025
Key Laboratory of Advanced Energy Materials Chemistry, College of Chemistry, Weijin Road 94, 300071, Tianjin, CHINA.
Background: An advantage of blood-based biomarkers of Alzheimer's disease (AD) is that collection is easily repeatable and minimally invasive. Repeated biomarker measurements provide greater sensitivity for detecting within-person change, which in clinical trials can allow for reductions in sample sizes required to detect treatment effects and shorten trial periods. We validated Dried Blood Spots (DBS) as a novel matrix for measuring blood biomarkers of AD, as collection is easily repeatable, less burdensome for participants, and more economical than phlebotomy, and shipment and storage are simplified.
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