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Controlled Inflammation Drives Neutrophil-Mediated Precision Drug Delivery in Heterogeneous Tumors.
Adv Sci (Weinh)
January 2025
Department of Radiology, The Second Hospital of Tianjin Medical University, Tianjin, 300211, P. R. China.
Tumor heterogeneity remains a formidable obstacle in targeted cancer therapy, often leading to suboptimal treatment outcomes. This study presents an innovative approach that harnesses controlled inflammation to guide neutrophil-mediated drug delivery, effectively overcoming the limitations imposed by tumor heterogeneity. By inducing localized inflammation within tumors using lipopolysaccharide, it significantly amplify the recruitment of drug-laden neutrophils to tumor sites, irrespective of specific tumor markers.
View Article and Find Full Text PDFOxidative/Nitrosative Stress, Apoptosis, and Redox Signaling: Key Players in Neurodegenerative Diseases.
J Biochem Mol Toxicol
January 2025
Department of Medical Biochemistry, Faculty of Medicine, Kahramanmaraş Sütçü İmam University, Kahramanmaraş, Turkey.
Neurodegenerative diseases are significant health concerns that have a profound impact on the quality and duration of life for millions of individuals. These diseases are characterized by pathological changes in various brain regions, specific genetic mutations associated with the disease, deposits of abnormal proteins, and the degeneration of neurological cells. As neurodegenerative disorders vary in their epidemiological characteristics and vulnerability of neurons, treatment of these diseases is usually aimed at slowing disease progression.
View Article and Find Full Text PDFProgress in the Study of TAp73 and Sperm Apoptosis.
Cell Biochem Funct
January 2025
Department of Physiology and Pharmacology, Anhui University of Chinese Medicine, Hefei, Anhui, China.
The study of the mechanism of oligoasthenospermia, which is a major cause of male infertility, has been the focus of research in the field of male reproduction. TAp73, a member of the p53 family of oncogenes, is endowed with tumor-suppressing activity due to its structural and functional homology with p53. It has been found that TAp73, plays a key role in spermatogenesis and maintaining male reproduction.
View Article and Find Full Text PDFSnake venom galactoside-binding lectin from Bothrops jararacussu: Special role in leukocytes activation and function.
Int J Biol Macromol
January 2025
Fundação de Medicina Tropical - Dr Heitor Vieira Dourado, Manaus, AM, Brazil; Universidade Nilton Lins, Manaus, AM, Brazil. Electronic address:
Article Synopsis
- SVgalLs are toxins from Bothrops snake venoms that bind to galactose-containing carbohydrates in a calcium-dependent way.
- BjcuL, a key C-type lectin from Bothrops jararacussu venom, has been extensively studied for its role in inflammation by activating immune cell functions.
- The review discusses the current knowledge on snake venom lectins' effects in pathophysiology and outlines future research directions, including advanced technologies for discovering new therapeutic targets.
Clay-catalyzed ozonation of Norfloxacin - Effects of metal cation and degradation rate on aqueous media toxicity towards Lemna minor.
Chemosphere
January 2025
Nanoqam, Department of Chemistry, University of Quebec at Montreal, H3C 3P8, Canada; École de technologie supérieure, Montréal (Québec), Canada, H3C 1K3. Electronic address:
Article Synopsis
- Norfloxacin was ozonized in clay suspensions to study its toxicity on Lemna minor, which helps assess antibiotic impact in environments with clay.
- The study found that norfloxacin causes toxicity in Lemna minor through oxidative stress, worsened by ozonation, affecting growth and chlorophyll levels.
- Results indicate that the type of clay catalyst and the oxidation process influence the toxicity outcomes, revealing the potential formation of more harmful byproducts from the antibiotic.
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