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Durvalumab with or without bevacizumab with transarterial chemoembolisation in hepatocellular carcinoma (EMERALD-1): a multiregional, randomised, double-blind, placebo-controlled, phase 3 study.
Lancet
January 2025
Department of Diagnostic and Interventional Radiology, University of Pisa School of Medicine, Pisa, Italy.
Background: Transarterial chemoembolisation (TACE) is standard of care for patients with unresectable hepatocellular carcinoma that is amenable to embolisation; however, median progression-free survival is still approximately 7 months. We aimed to assess whether adding durvalumab, with or without bevacizumab, might improve progression-free survival.
Methods: In this multiregional, randomised, double-blind, placebo-controlled, phase 3 study (EMERALD-1), adults aged 18 years or older with unresectable hepatocellular carcinoma amenable to embolisation, an Eastern Cooperative Oncology Group performance status of 0 or 1 at enrolment, and at least one measurable intrahepatic lesion per modified Response Evaluation Criteria in Solid Tumours (RECIST) were enrolled at 157 medical sites including research centres and general and specialist hospitals in 18 countries.
Ethical considerations for referral partnerships in clinical research.
J Med Ethics
December 2024
Department of Bioethics, The Clinical Center, National Institutes of Health, Bethesda, Maryland, USA
Recruitment challenges in clinical research are widespread, particularly for traditionally under-represented groups. Referral relationships-in which research partners and clinical partners agree to collaborate on selected research studies or programmes, with the expectation that the clinical partners refer appropriate patients as potential participants-may help alleviate these challenges. Referral relationships allow research partners access to expanded and more diverse pools of participants by increasing the engagement of medical providers, leveraging providers' connections with patients and providing structural support for study participation.
View Article and Find Full Text PDFRoger Alberto - Curiosity, Passion, Excellence.
Chemistry
January 2025
University of Zurich, Department of Chemistry, Winterthurerstrasse 190, 8057, Zurich, Switzerland.
Prof. Dr. Roger Alberto - A Special Collection of articles honouring an outstanding scientist, collaborator, and friend.
View Article and Find Full Text PDFWine tasting Demystified: Celebrating Professor Wendy Parr's contribution to the understanding of wine tasting and wine tasters - An Introduction.
Food Res Int
January 2025
CSGA, Dijon, France.
Our goal in putting together this special issue was twofold: First, to honour the remarkable career of Professor Wendy Parr and her contribution to the understanding of wine tasting and wine tasters and second, to continue to raise awareness of the importance of the cognitive approach in the wine scientific literature. We present Professor Wendy Parr's insightful reflections on her distinguished career, including her early ventures into psychology and the experiences that shaped her contributions. These are complemented by a concise historical perspective on the evolution of wine sensory science, providing context for her work.
View Article and Find Full Text PDFCulture of honour and the stigma of abortion.
Psychol Health
January 2025
University of Groningen, Groningen, Netherlands.
Access to safe abortion is critical for women's health, but women are stigmatised for seeking out an abortion due to social norms regarding gender roles and sexuality. This abortion stigma is likely more prevalent in U.S.
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