AI Article Synopsis
- Glycans' structural complexity makes it difficult to chemically synthesize glycosides, oligosaccharides, and glycoconjugates, more so than DNA and proteins.
- The synthesis of glycosides, while based on a straightforward bond-forming reaction, is considered one of the toughest challenges in organic chemistry.
- This text discusses the basic principles of forming glycoside bonds and highlights recent breakthroughs in the synthesis of glycosides and oligosaccharides.
Article Abstract
The structural complexity of glycans poses a serious challenge in the chemical synthesis of glycosides, oligosaccharides and glycoconjugates. Glycan complexity, determined by composition, connectivity, and configuration far exceeds what nature achieves with nucleic acids and proteins. Consequently, glycoside synthesis ranks among the most complex tasks in organic synthesis, despite involving only a simple type of bond-forming reaction. Here, we introduce the fundamental principles of glycoside bond formation and summarize recent advances in glycoside bond formation and oligosaccharide synthesis.
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| http://dx.doi.org/10.1039/d3cs00321c | DOI Listing |
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