[Nephroprotection: General principles and application to the patients with cancers - when nephroprotection is essential for oncological care plan].

Bull Cancer

Assistance publique-Hôpitaux de Paris (AP-HP), centre hospitalier universitaire de Bicêtre, université de Paris-Saclay, service de néphrologie, dialyse et transplantation, Le Kremlin-Bicêtre, France.

Published: July 2024

AI Article Synopsis

  • * Cancer patients face unique risks of renal issues due to specific treatments and are often not adequately represented in nephroprotection studies, leading to gaps in current guidelines.
  • * The article emphasizes adapting nephroprotection strategies for cancer patients, focusing on education, managing comorbidities, and the need for collaboration between oncologists and nephrologists to develop the emerging field of onco-nephrology.

Article Abstract

Nephroprotection is a set of recommendations that aim to prevent the risks of acute and/or chronic renal failure and to limit the progression of renal failure towards an end stage. Nephroprotection is not limited to nephrology and applies to all patients at risk of renal failure. Cancer patients are particularly at risk of developing intrinsic and extrinsic renal failure, as well as the toxicity of specific treatments. However, they are poorly included in nephroprotection studies. Thus, current guidelines have not been adapted to these pathologies and oncology-specific comorbidities, such as malnutrition or prognosis, are often not taken into account. In this article, we review the established recommendations by transposing them to the cancer patient as a whole. In addition to the reminder of hygiene and dietary rules to control blood pressure and diabetes, we discuss the importance of therapeutic education, iatrogeny and treatment options to control renal failure in this context. The lack of clearly established data in cancer confirms the needs to strengthen links between oncologists, hematologists and nephrologists and reinforces the emergence of onco-nephrology as a new discipline.

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Source
http://dx.doi.org/10.1016/j.bulcan.2023.05.011DOI Listing

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