AI Article Synopsis
- Psoriasis involves excessive skin cell growth and immune cell infiltration, with the exact causes remaining uncertain.
- Researchers found that glycyl-tRNA synthetase (GARS), typically involved in protein synthesis, is overexpressed in the skin and blood of psoriasis patients, promoting skin inflammation and abnormal growth when present in high levels.
- The study suggests that targeting GARS could be a potential new treatment strategy for psoriasis, as reducing its expression showed improvements in inflammation and skin condition in laboratory models.
Article Abstract
Psoriasis is characterized by excessive keratinocyte proliferation and immunocyte infiltration, but the underlying pathogenesis remains unclear. Aminoacyl-tRNA synthetases are universally expressed enzymes that catalyze the first step of protein synthesis. Glycyl-tRNA synthetase (GARS) is a member of the aminoacyl-tRNA synthetase family. In addition to its canonical function, we found that GARS was overexpressed in the serum and skin lesions of patients with psoriasis. Moreover, GARS was highly expressed in human skin keratinocytes, and GARS knockdown in keratinocytes suppressed cell proliferation and promoted apoptosis through NF-κB/MAPK signaling pathway. Moreover, intradermal injection of recombinant GARS protein caused skin thickening, angiogenesis, and IFN/TNF-driven skin inflammation. Intriguingly, the reported functional receptor for GARS, cadherin 6 (CDH6), was specifically expressed in vascular endothelial cells, and we found that keratinocyte-derived GARS promotes inflammation and angiogenesis of vascular endothelial cells through CDH6. In addition, intradermal injection of GARS aggravated the phenotype and angiogenesis in imiquimod-induced psoriasiform dermatitis models, whereas the psoriatic phenotype and angiogenesis were relieved after knockdown of GARS by adeno-associated virus. Taken together, the results of this study identify the critical role of GARS in the pathogenesis of psoriasis and suggest that blocking GARS may be a therapeutic approach for alleviating psoriasis.
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| http://dx.doi.org/10.1016/j.jid.2023.09.270 | DOI Listing |
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