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Exploring the significant genetic diversity of Iranian isolates of Leishmania RNA virus 2 using whole genome sequence analysis.
BMC Infect Dis
December 2024
Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Background: Our work presents the whole genome sequence and phylogenetic analysis of five Leishmania RNA virus 2 (LRV2) isolates obtained from patients with cutaneous leishmaniasis (CL) in Iran.
Methods: The whole genome sequencing of LRV2 was performed using a primer walking approach. The resulting sequences were analyzed for genetic and haplotype diversity, highlighting their independent evolution and significant genetic divergence.
The burden and trend of intestinal parasitosis among women at Berekum, Ghana: a 9-year retrospective study.
BMC Infect Dis
November 2024
Department of Biomedical Sciences, School of Basic and Biomedical Sciences, University of Health and Allied Sciences, Ho, Ghana.
Article Synopsis
- Intestinal parasitic infections (IPIs) are significant public health concerns, particularly in low and middle-income countries, where they can severely affect vulnerable populations through contaminated food and water.
- A study analyzing 9 years of stool examination data found an overall prevalence of 21.20% of IPIs, with the highest rates among patients aged 70-79 and in the year 2020.
- The most common parasites identified were intestinal flagellates, which accounted for 98.31% of the infections diagnosed in the study.
Epidemiology and clinical description of Chagas disease in Valencia, Spain, from 2010 to 2020.
Acta Trop
December 2024
Unidad de Enfermedades Infecciosas, Servicio de Medicina Interna, Hospital Universitario y Politécnico La Fe, University of Valencia-Health Research Institute La Fe, Valencia, Spain.
Article Synopsis
- * A study at Hospital Universitari i Politécnic in Valencia, Spain, from 2010 to 2020 analyzed 3713 cases, revealing an 11.7% prevalence, primarily among women of childbearing age, with many patients undiagnosed and untreated.
- * Treatment with the drug benznidazole led to adverse reactions in 107 out of 204 patients, highlighting the challenges CD poses for healthcare systems and the importance of raising awareness about the disease.
The association of serum level and polymorphisms of IFN-γ (rs2069705) with the susceptibility to cutaneous leishmaniasis.
Cytokine
December 2024
College of Medicine, University of Diyala, Diyala governorate, Iraq.
Leishmaniasis, a broad range of parasitic diseases, caused by Leishmania which is a flagellated intracellular protozoan parasite of the family Trypanosomatidae. The severity of leishmaniasis diseases ranges from minor cutaneous lesions to severe visceral illnesses that can be disfiguring and life-threatening. Cytokines are glycoprotein molecules produced by various cells in response to various immunological triggers.
View Article and Find Full Text PDFInhibition of Giardia duodenalis by isocryptolepine -triazole adducts and derivatives.
Int J Parasitol Drugs Drug Resist
December 2024
Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. Electronic address:
Giardia duodenalis, a widespread parasitic flagellate protozoan causing giardiasis, affects millions annually, particularly impacting children and travellers. With no effective vaccine available, treatment primarily relies on the oral administration of drugs targeting trophozoites in the small intestine. However, existing medications pose challenges due to side effects and drug resistance, necessitating the exploration of novel therapeutic options.
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