AI Article Synopsis
- * By using single-nucleus chromatin accessibility data, we mapped out the gene regulatory networks and transcription factors crucial for the development of different cortical lineages.
- * Our findings linked certain cortical cell types to genetic risk factors for brain disorders like autism, revealing that female cells show greater susceptibility due to upregulated lineage-specific gene expression related to these risks.
Article Abstract
We analyzed >700,000 single-nucleus RNA sequencing profiles from 106 donors during prenatal and postnatal developmental stages and identified lineage-specific programs that underlie the development of specific subtypes of excitatory cortical neurons, interneurons, glial cell types, and brain vasculature. By leveraging single-nucleus chromatin accessibility data, we delineated enhancer gene regulatory networks and transcription factors that control commitment of specific cortical lineages. By intersecting our results with genetic risk factors for human brain diseases, we identified the cortical cell types and lineages most vulnerable to genetic insults of different brain disorders, especially autism. We find that lineage-specific gene expression programs up-regulated in female cells are especially enriched for the genetic risk factors of autism. Our study captures the molecular progression of cortical lineages across human development.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11005279 | PMC |
| http://dx.doi.org/10.1126/science.adf0834 | DOI Listing |
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