Characterization of a DsbA family protein reveals its crucial role in oxidative stress tolerance of .

Microbiol Spectr

College of Animal Science and Technology &College of Veterinary Medicine, Zhejiang A&F University, Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, Zhejiang Provincial Engineering Research Center for Animal Health Diagnostics & Advanced Technology, Zhejiang International Science and Technology Cooperation Base for Veterinary Medicine and Health Management, China-Australia Joint Laboratory for Animal Health Big Data Analytics , Hangzhou, Zhejiang, China.

Published: December 2023

The adaption and tolerance to various environmental stresses are the fundamental factors for the widespread existence of . Anti-oxidative stress is the critical mechanism for the survival and pathogenesis of . The thioredoxin (Trx) and glutaredoxin (Grx) systems are known to contribute to the anti-oxidative stress of , but whether the Dsb system has similar roles remains unknown. This study demonstrated that the DsbA family protein Lmo1059 of participates in bacterial oxidative stress tolerance, with Cys36 as the key amino acid of its catalytic activity and anti-oxidative stress ability. It is worth noting that Lmo1059 was involved in the invading and cell-to-cell spread of . This study lays a foundation for further understanding the specific mechanisms of oxidative cysteine repair and antioxidant stress regulation of , which contributes to an in-depth understanding of the environmental adaptation mechanisms for foodborne bacterial pathogens.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10715225PMC
http://dx.doi.org/10.1128/spectrum.03060-23DOI Listing

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