AI Article Synopsis
- Centrosomes are crucial for organizing microtubules in cells, with sperm containing a specialized structure made up of different centrioles and pericentriolar material.
- Researchers studied the localization of centriole proteins CEP135 and CP110 in cattle and human sperm, both of which play roles in centriole structure and cilia formation.
- The antibodies used in the study identified CEP135 and CP110 near the expected locations in sperm centrioles, highlighting the unique functions of centrosomes in sperm development.
Article Abstract
Centrosomes play an important role in the microtubule organization of a cell. The sperm's specialized centrosome consists of the canonical barrel-shaped proximal centriole, the funnel-shaped distal centriole, and the pericentriolar material known as striated columns (or segmented columns). Here, we examined the localization of the centriole proteins CEP135 and CP110 in cattle and human spermatozoa. In canonical centrioles, CP110 is a centriole tip protein that controls cilia formation, while CEP135 is a structural protein essential for constructing the centriole. In contrast, we found antibodies recognizing CEP135 and CP110 label near the proximal and distal centrioles at the expected location of the striated columns and capitulum in cattle and humans in an antibody and species-specific way. These findings provide a pathway to understanding the unique functions of spermatozoan centrosome.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10562935 | PMC |
| http://dx.doi.org/10.17912/micropub.biology.000951 | DOI Listing |
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