Correlation between Antimicrobial Resistant and Severity of Acne Vulgaris: Findings from a Tertiary Hospital.

The study of antimicrobial-resistant was not conducted regularly, especially in Indonesia. Conversely, regular monitoring of antibiotic efficacy through testing to assess the evolution of current resistance patterns is obligated; thus, filling the gap caused by a lack of appropriate antibiotic surveillance is required. Analyse the correlation between resistance patterns of to doxycycline, clindamycin, erythromycin and azithromycin with the severity of acne vulgaris. This is an analytic observational laboratory study with a cross-sectional design of mild to severe acne vulgaris (AV) patients. Specimens were obtained from comedones of 71 patients, which were cultured and identified using biochemical examination. Antimicrobial resistance (doxycycline, clindamycin, erythromycin and azithromycin) to was tested by disc diffusion method. Among 71 samples collected, 40 (56.3%) isolates were cultured and identified. The incidence of resistance to more than one antimicrobial was 45%. Antimicrobial resistances were clindamycin 42.5%, erythromycin 40%, azithromycin 23.5% and doxycycline 12.5%, respectively. According to the contingency coefficient test, there was moderate correlation between the resistance pattern of to clindamycin ( = 0.485, = <0.001) and doxycycline ( = 0.433, = 0.002) and AV severity. There was weak correlation between the resistance pattern of to erythromycin ( = 0.333; = 0.025) and azithromycin ( = 0.321; = 0.032) and AV severity. In conclusion, there is a correlation between the pattern of resistance to doxycycline, clindamycin, erythromycin, azithromycin and severity of AV.