AI Article Synopsis
- The study explores the antifouling effects of three polyphenolic resveratrol multimers, isolated from Papua New Guinean rainforest species, against marine microfoulers and barnacle larva settlements.
- Two compounds, (-)-hopeaphenol and vaticanol B, showed strong inhibition of barnacle larvae metamorphosis and were effective at low concentrations, particularly (-)-hopeaphenol which also inhibited microalgal and bacterial adhesion.
- In comparison, resveratrol itself had lower antifouling effectiveness and higher toxicity against certain cell lines, highlighting the potential for natural products to provide safer alternatives for antifouling agents.
Article Abstract
In the current study we investigate the antifouling potential of three polyphenolic resveratrol multimers (-)-hopeaphenol, vaticanol B and vatalbinoside A, isolated from two species of found in the Papua New Guinean rainforest. The compounds were evaluated against the growth and settlement of eight marine microfoulers and against the settlement and metamorphosis of barnacle cyprids. The two isomeric compounds (-)-hopeaphenol and vaticanol B displayed a high inhibitory potential against the cyprid larvae metamorphosis at 2.8 and 1.1 μM. (-)-Hopeaphenol was also shown to be a strong inhibitor of both microalgal and bacterial adhesion at submicromolar concentrations with low toxicity. Resveratrol displayed a lower antifouling activity compared to the multimers and had higher off target toxicity against MCR-5 fibroblasts. This study illustrates the potential of natural products as a valuable source for the discovery of novel antifouling leads with low toxicity.
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| http://dx.doi.org/10.1080/08927014.2023.2263374 | DOI Listing |
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- The study explores the antifouling effects of three polyphenolic resveratrol multimers, isolated from Papua New Guinean rainforest species, against marine microfoulers and barnacle larva settlements.
- Two compounds, (-)-hopeaphenol and vaticanol B, showed strong inhibition of barnacle larvae metamorphosis and were effective at low concentrations, particularly (-)-hopeaphenol which also inhibited microalgal and bacterial adhesion.
- In comparison, resveratrol itself had lower antifouling effectiveness and higher toxicity against certain cell lines, highlighting the potential for natural products to provide safer alternatives for antifouling agents.
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