Incomplete merging of the Müllerian ducts may result in vaginal septa or even completely separate vaginal canals. It may also cause cervical malformation. In most cases, there are only rudimentary vaginal septations. Only a few reports describing completely separated vaginal canals (vagina duplex) and a cervix duplex in dogs have been published. This article reports the case of a bitch presented with recurrent vaginitis and cystitis. The symptoms always appeared following the dog's heat. The bitch had been pre-treated by a prior veterinarian as well as in a prior clinic. When presented in the clinic, a vaginal septum was suspected based on digital vaginal examination. Ultrasonographic examination and urinalysis allowed for the diagnosis of bacterial cystitis, which was subsequently treated with antibiotics. The bitch was presented again for vaginal endoscopy, transection of the vaginal septum, and ovariohysterectomy. Both vagina duplex and cervix duplex were diagnosed. Due to the extensive dimensions of the findings, the altered tissue was not resected. No more bacteria were detected in a repeated urine analysis. After spaying, the bitch showed no recurrence of symptoms of cystitis or vaginitis.
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http://dx.doi.org/10.1055/a-2122-5408 | DOI Listing |
Oncogene
July 2024
Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.
Somatic TP53 mutations are prevalent in normal tissue but little is known about their association with cancer risk. Cervical liquid-based cytology (LBC), commonly known as Pap test, provides an accessible gynecological sample to test the value of TP53 somatic mutations as a biomarker for high-grade serous ovarian cancer (HGSC), a cancer type mostly driven by TP53 mutations. We used ultra-deep duplex sequencing to analyze TP53 mutations in LBC and blood samples from 70 individuals (30 with and 40 without HGSC) undergoing gynecologic surgery, 30 carrying BRCA1 or BRCA2 germline pathogenic variants (BRCApv).
View Article and Find Full Text PDFHeliyon
June 2024
Center for Global Health Research, Saveetha Medical College & Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Thandalam, Chennai, 602 105, Tamil Nadu, India.
Cervical cancer is caused by changes in the cervix that lead to precancerous cells and eventually progress to cancer. Human papillomavirus (HPV) infections are the primary cause of cervical cancer. Early detection of HPV is crucial in preventing cervical cancer, and regular screening for HPV infection can identify cell changes before they develop into cancer.
View Article and Find Full Text PDFTierarztl Prax Ausg K Kleintiere Heimtiere
August 2023
Tierklinik Dinkelsbühl GmbH, Dinkelsbühl.
Incomplete merging of the Müllerian ducts may result in vaginal septa or even completely separate vaginal canals. It may also cause cervical malformation. In most cases, there are only rudimentary vaginal septations.
View Article and Find Full Text PDFFront Oncol
March 2023
Department of Radiology, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Gastric-type endocervical adenocarcinoma (G-EAC) is a rare special type of cervical mucinous adenocarcinomas, and it is reported the incidence is unrelated to human papilloma virus infection. We report a rare case of G-EAC in stumps of duplicated cervices in a 49-year-old female patient. The woman complained of post-coital bleeding.
View Article and Find Full Text PDFCurr Top Dev Biol
April 2022
Department of Genetics, University of Texas M.D. Anderson Cancer Center, Houston, TX, United States; Program in Genetics and Epigenetics, MD Anderson Cancer Center UT Health Graduate School of Biomedical Sciences, Houston, TX, United States; Program in Developmental Biology, Baylor College of Medicine, Houston, TX, United States. Electronic address:
In eutherian and marsupial mammals, the site of embryo implantation and gestation is the uterus. Uterine morphologies vary between mammalian species. For example, laboratory mice have a bipartite uterus with two uterine horns and a single cervix, whereas humans have a simplex uterus with a single chamber and single cervix.
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