AI Article Synopsis
- The occurrence of combined central and peripheral demyelination (CCPD) is uncommon, primarily documented in small studies focused on adults.
- A case study of a 7-year-old girl illustrates the potential for anti-MOG antibody positivity to vary and links to a diagnosis of MOGAD associated with CCPD.
- Clinicians should consider CCPD in children when assessing atypical demyelination cases, as this awareness can influence diagnosis and treatment strategies.
Article Abstract
The occurrence of combined central and peripheral demyelination (CCPD) is rare, data are limited to small case and cohort studies, mainly concerning adults. In few patients positivity to anti MOG antibody is reported, thus widening the spectrum of anti-MOG associated disorders (MOGAD). We describe a 7-year-old girl with optic neuritis followed 8 years later by peripheral demyelination, with fluctuating anti-MOG antibody positivity at cell-based assay. From the review of the literature, MOGAD-CCPD appear very rare in childhood, especially with asynchronous course. Clinicians should keep this possibility in mind to better define diagnosis in atypical demyelination syndromes, with therapeutical implications.
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| http://dx.doi.org/10.1016/j.jneuroim.2023.578213 | DOI Listing |
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