Accidental inhalation intake of plutonium isotopes and 241Am occurred at a Pu research facility in Japan in 2017, and the five workers involved in this accident were treated by the administration of Ca/Zn-diethylenetriaminepentaacetic acid (DTPA). For the worker who was most internally exposed, the therapy was continued over 1 y after the accident. Urinary samples collected before and after each administration were subject to bioassay to evaluate the efficacy of the dose reduction. This study performed numerical analyses using a biokinetic model dealing with 241Am-DTPA with reference to the European Coordinated Network on Radiation Dosimetry approach, which assumes that the complex of actinides and Ca/Zn-DTPA is generated in the designated compartments in the biokinetic model. The results of the model prediction well captured the trend of the observed urinary excretion in the long-term bioassay and would be useful to evaluate the efficacy of the Ca/Zn-DTPA administration for the worker involved in the accident.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1093/rpd/ncac224 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Analysis of biokinetic parameters reveals patterns in mercury accumulation across aquatic species.
Sci Total Environ
December 2024
Oak Ridge National Laboratory, Environmental Sciences Division, Oak Ridge, TN, United States of America.
Article Synopsis
- Mercury is a toxic substance that accumulates in fish, particularly in its organic form, methylmercury (MeHg), which poses risks to human health through contaminated fish consumption.
- Understanding how mercury accumulates in aquatic species requires analyzing several biokinetic parameters, including uptake rate, assimilation efficiency, and efflux rate, which were studied across 38 fish and 34 aquatic invertebrate species, yielding 502 total data points.
- The study found that the form of mercury and various environmental factors like water type and organism weight significantly influenced these parameters, highlighting differences between fish and invertebrates, and challenging previous assumptions about the impact of environmental conditions on mercury accumulation in aquatic ecosystems.
Distribution of plutonium and radium in the human heart.
J Radiol Prot
December 2024
Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York, UNITED STATES.
Since 1968, the United States Transuranium and Uranium Registries (USTUR) has studied the biokinetics and tissue dosimetry of uranium and transuranium elements in nuclear workers. As part of the USTUR collaboration with the Million Person Study (MPS) of Low-Dose Health Effects, radiation dose to different parts of the human heart is being estimated for workers with documented intakes of 239Pu or 226Ra. The study may be expanded for workers with intakes of 238U and other radionuclides.
View Article and Find Full Text PDFIodine transfer to dairy cow's milk: A revised biokinetic model.
J Hazard Mater
December 2024
Faculty of Biosciences, Norwegian University of Life Sciences, PO Box 5003, Ås N-1432, Norway.
A new biokinetic model for iodine in dairy cows was developed utilizing data from a 4 × 4 factorial feeding experiment with rumen-cannulated cows that were fed rapeseed cake containing substances known to influence iodine metabolism, and soybean meal without such effects. I was administered both intravenously and intra-ruminally to document metabolism pathways. The new model included compartments such as saliva and thyroid gland, often ignored in other models, and in contrast to previously available biokinetic models, it fitted well to our experimental data.
View Article and Find Full Text PDFSingle-time-point dosimetry using model selection and the Bayesian fitting method: A proof of concept.
Phys Med
December 2024
Medical Radiation Physics, Department of Nuclear Medicine, Ulm University, Ulm, Germany.
Purpose: This study aimed to determine the effect of model selection on simplified dosimetry for the kidneys using Bayesian fitting (BF) and single-time-point (STP) imaging.
Methods: Kidney biokinetics data of [Lu]Lu-PSMA-617 from mHSPC were collected using SPECT/CT after injection of (3.1 ± 0.
Few-time-points time-integrated activity coefficients calculation using non-linear mixed-effects modeling: Proof of concept for [In]In-DOTA-TATE in kidneys.
Phys Med
December 2024
Department of Nuclear Medicine, Ulm University, Ulm, Germany; Medical Radiation Physics, Department of Nuclear Medicine, Ulm University, Ulm, Germany.
Purpose: The purpose of this study is to investigate the accuracy of few-time-points (FTP) time-integrated activity coefficients (TIACs) in peptide-receptor radionuclide therapy (PRRT) using non-linear mixed-effects (NLME) modeling.
Methods: Biokinetic data of [In]In-DOTA-TATE in kidneys at T-1 = (2.9 ± 0.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!