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A Probabilistic Modeling Framework for the Prediction of Spontaneous Premature Beats and Reentry Initiation.
Heart Rhythm
January 2025
Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, MD, USA. Electronic address:
Background: Spontaneously occurring life threatening reentrant arrhythmias result when a propagating premature beat encounters a region with significant dispersion of refractoriness. Although localized structural tissue heterogeneities and prescribed cell functional gradients have been incorporated into computational electrophysiological models, a quantitative framework for the evolution from normal to abnormal behavior that occurs via disease is lacking.
Objective: The purpose of this study was to develop a probabilistic modeling framework that represents the complex interplay of cell function and tissue structure in health and disease which predicts the emergence of premature beats and the initiation of reentry.
Lewy‐related pathology in the Tampere Sudden Death Study.
Alzheimers Dement
December 2024
University of Helsinki, Helsinki, Uusimaa, Finland
Background: When treatments against neurodegenerative diseases eventuate, the most successful time point to administer therapies will be the early stages, most likely before symptoms begin to show. Previous studies have found alpha‐synuclein pathology (Lewy‐related pathology; LRP) in asymptomatic individuals aged 62 years and above, with ranges from 8 to 17%.
Method: We performed immunohistochemical staining with the 5G4 antibody against alpha‐synuclein on brain tissue samples from the Tampere Sudden Death Study – a collection of forensic autopsies on individuals that lived outside hospital institutions in Tampere and the surrounding regions, Finland.
Passive amylin immunotherapy improves brain function and reduces brain β‐amyloid pathology in APP/PS1 mice.
Alzheimers Dement
December 2024
University of Kentucky, Lexington, KY, USA
Background: Amylin is a systemic hormone that is co‐secreted with insulin from pancreatic β‐cells. Amylin co‐aggregates with brain parenchymal and vascular β‐amyloid in persons with Alzheimer’s dementia. The present pilot study sought to assess the safety and side effects during and after the treatment period of passive amylin immunotherapy in the APP/PS1 mouse model of Alzheimer’s disease.
View Article and Find Full Text PDFGenetically engineered biomimetic ATP-responsive nanozyme for the treatment of cardiac fibrosis.
J Nanobiotechnology
January 2025
Department of Laboratory, Tangdu Hospital, Fourth Military Medical University, Xi'an, 710032, China.
Background: Cardiac fibrosis plays a critical role in the progression of various forms of heart disease, significantly increasing the risk of sudden cardiac death. However, currently, there are no therapeutic strategies available to prevent the onset of cardiac fibrosis.
Methods And Results: Here, biomimetic ATP-responsive nanozymes based on genetically engineered cell membranes are adapted to specifically recognize activated cardiac fibroblasts (CFs) for the treatment of cardiac fibrosis.
First Incidence of Peste des Petits Ruminants Virus in Family from State Zoo of Assam, India.
Viruses
November 2024
College of Veterinary Science, Assam Agricultural University, Guwahati 781022, Assam, India.
The present study aimed to investigate the episodes of per-acute mortality due to peste des petits ruminants (PPR) that resulted in the death of 30 animals of different species of cervids, namely, barking deer, four-horned antelope, hog deer, thamin, and mouse deer in the State Zoo of Assam, a northeastern state of India. The affected animals showed no to limited clinical signs. However, the necropsy and histopathological findings were highly suggestive of PPR virus (PPRV) infection observed in domestic small ruminants.
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