In this study, we explored the lifespan extension effect of a popular edible mushroom, , using the model organism (). The results showed that extract (HME) could increase the lifespan of and ameliorate the healthspan by improving motility, attenuating lipofuscin accumulation, and enhancing the ability to withstand oxidative and heat stress. Then, we found noteworthy enhancements in SOD and CAT activities and reactive oxygen species (ROS) scavenging activity . Combined with the up-regulation of the expression of antioxidant genes (, , , and ), HME may function as an antioxidant in nematodes, which may be closely related to its phenolic compounds. Furthermore, we found that HME promoted the transfer of the transcription factor SKN-1 to the nucleus but had no impact on the lifespan of mutants, indicating that SKN-1 was essential for to exert beneficial biological effects in . Our findings elucidated that dietary supplementation with might have beneficial anti-aging effects and contribute to exploring the lifespan extension and underlying mechanisms of in .
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