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MagIC beads for scarce macromolecules.
Elife
January 2025
Laboratory of Biophysical Chemistry of Macromolecules, Institute of Chemical Sciences and Engineering (ISIC), School of Basic Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Specialized magnetic beads that bind target proteins to a cryogenic electron microscopy grid make it possible to study the structure of protein complexes from dilute samples.
View Article and Find Full Text PDFSynthesis, characterization, and computational evaluation of some synthesized xanthone derivatives: focus on kinase target network and biomedical properties.
Front Pharmacol
January 2025
Department of Surgical Sciences, Functional Pharmacology and Neuroscience, Uppsala University, Uppsala, Sweden.
Background: Xanthones are dubbed as putative lead-like molecules for cancer drug design and discovery. This study was aimed at the synthesis, characterization, and target fishing of novel xanthone derivatives.
Methods: The products of reactions of xanthydrol with urea, thiourea, and thiosemicarbazide reacted with α-haloketones to prepare the thiazolone compounds.
Myocardial scar detection in patients with implantable cardiac device: Wideband free-breathing motion-corrected black-blood late gadolinium enhancement could be the answer.
Diagn Interv Imaging
January 2025
Univ. Lille, CHU Lille, INSERM, Institut Pasteur Lille, U1011-European Genomic Institute for Diabetes (EGID), 59000 Lille, France.
Potential benefits and mechanisms of physical exercise and rTMS in improving brain function in people with drug use disorders.
Gen Hosp Psychiatry
January 2025
Research Centre for Exercise Detoxification, College of Physical Education, Southwest University, Chongqing 400715, China. Electronic address:
Improving brain function impairment in people with substance use disorders (PSUD) is considered to be important in regulating their cyclic drug use impulse and relapse behavior. Physical exercise (PE) and repetitive transcranial magnetic stimulation (rTMS) may improve brain functional impairment in PSUD, respectively, but few studies have focused on the benefits and mechanisms of the combined use of the two. This editorial presents: 1) Both PE and rTMS alone appear to have positive effects on PSUD's reward system, cognitive function, and emotional regulation to varying degrees.
View Article and Find Full Text PDFMagnetic resonance imaging evaluation and nuclear receptor binding SET domain protein 1 mutation in the Sotos syndrome with attention-deficit/hyperactivity disorder.
World J Clin Cases
January 2025
Shanghai XiRong Information Science and Technology Co., Ltd, National Science and Technology Park, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.
Sotos syndrome is characterized by overgrowth features and is caused by alterations in the gene. Attention-deficit/hyperactivity disorder (ADHD) is considered a neurodevelopment and psychiatric disorder in childhood. Genetic characteristics and clinical presentation could play an important role in the diagnosis of Sotos syndrome and ADHD.
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