Nitroso derivatives with unique characteristics have been extensively studied in various fields, including biology and clinical research. Although there has been substantial investigation of "nitrosable" components in many drugs and commonly consumed nutrients, there is still a need for a higher awareness about their formation and characterization. This study demonstrates how these derivatives can be produced through a mechanochemical procedure under solid-state conditions. The results include synthesizing previously unknown compounds with potential biological and pharmaceutical applications, such as a nitrosamine derived from a Diclofenac-like structure.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/cssc.202301034 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Recent advances in the synthetic applications of nitrosoarene chemistry.
Org Biomol Chem
December 2024
School of Chemical Engineering and Technology, Sun Yat-sen University, Zhuhai 519082, China.
Nitroso groups are widely present in biologically active compounds in medicinal chemistry, and nitroso compounds serve as important building blocks in organic chemistry and materials science. Nitrosoarenes, in particular, showcase remarkable versatility, functioning as both electrophilic and nucleophilic reagents in a broad spectrum of organic reactions, thereby holding significant relevance in organic chemistry. This review aims to provide a comprehensive overview of the latest advancements in nitrosoarene reactions spanning a decade.
View Article and Find Full Text PDFDisulfide-Containing Nitrosoarenes: Synthesis and Insights into Their Self-Polymerization on a Gold Surface.
Langmuir
December 2024
Department of Chemistry, Faculty of Science, University of Zagreb, Horvatovac 102A, HR-10000 Zagreb, Croatia.
Disulfide-containing nitrosoarenes with [bis(4-nitrosobenzyl) disulfide, ()] or without [4-nitrosophenyl disulfide, (), and 1,2-bis(4'-nitroso-[1,1'-biphenyl]-4-yl)disulfane, ()] an alkyl spacer between the sulfur headgroup and the aromatic moiety (phenyl in () or biphenyl in ()) were synthesized and used as precursors to form azodioxy thiolate films on Au(111) substrates. Due to the incorporated disulfide functionalities, these specifically designed nitrosoarenes are enabled to self-polymerize through azodioxy bonds on a gold surface. Thin films of (), (), and () were prepared at different adsorption times via the solution-phase self-assembly of molecules onto the Au(111) surface and characterized by Raman spectroscopy, ellipsometry, water contact angle measurements, atomic force microscopy (AFM), and scanning tunneling microscopy (STM).
View Article and Find Full Text PDFPublic Health Risks Associated with Food Process Contaminants - A Review.
J Food Prot
December 2024
Shenzhen Key Laboratory of Marine Microbiome Engineering, Institute for Advanced Study, Shenzhen University, Shenzhen 518060, China.
The increasing complexity of food production and processing has raised concerns regarding food process contaminants, which pose significant public health risks. Food process contaminants can be introduced during diverse phases of food processing such as drying, heating, grilling, and fermentation, resulting in the synthesis of harmful chemicals including acrylamide (AA), advanced glycation end products (AGEs), heterocyclic aromatic amines (HAAs), furan and its naturally occurring derivatives, polycyclic aromatic hydrocarbons (PAHs), N-nitroso compounds (NOCs), 2-chloropropane-1,2-diol esters (2-MCPDE), and 3-chloropropane-1,2-diol esters (3-MCPDE), ethyl carbamate (EC), glycidyl esters (GE), and 4-methylimidazole (4-MEI), all of these are harmful to human health. Although these compounds can be somewhat prevented during processing, eliminating them can often be challenging due to their unknown formation mechanism.
View Article and Find Full Text PDFWhole Genome Sequencing Analysis of Model Organisms Elucidates the Association Between Environmental Factors and Human Cancer Development.
Int J Mol Sci
October 2024
Department of Environmental Health Sciences, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan.
Article Synopsis
- This study investigates the mutational signatures related to -nitroso bile acid conjugates to understand their link to human cancer, particularly cholangiocarcinoma.
- Two key mutational signatures, B1 and B2, were identified; B1 is related to -nitroso-glycine, showing a specific mutation pattern that suggests its role in cancer development.
- The research indicates that exposure to certain chemicals like 1,2-DCP may lead to an inflammatory response in bile duct cells, which could promote cholangiocarcinoma through DNA damage and adduct formation.
Limosilactobacillus fermentum CGMCC 1.7434 and Debaryomyces hansenii GDMCC 2.149 synergize with ultrasound treatment to efficiently degrade nitrite in air-dried ducks.
Poult Sci
December 2024
State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Ningbo University, Ningbo, Zhejiang, 315211, China. Electronic address:
Nitrites in meat products are important food additives with coloring, antibacterial and antioxidant effects, but excessive intake of nitrites can pose health risks, including an increased risk of cancer due to the formation of carcinogenic nitrosamines. In the present study, Limosilactobacillus fermentum CGMCC 1.7434 was screened and the effects of it and Debaryomyces hansenii GDMCC 2.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!