AI Article Synopsis
- The study aimed to evaluate the HIV prevalence among patients diagnosed with gestational trophoblastic neoplasia (GTN) at the Sheffield Trophoblastic Disease Centre between 2015 and 2021.
- Out of 221 GTN patients, 93% were tested for HIV, revealing a prevalence rate of 1.3%, which equals 14 HIV-positive cases per 1,000 patients—significantly higher than the general population rates in Sheffield and Yorkshire.
- The findings suggest that routine 'opt out' HIV testing should be implemented for all GTD and GTN patients at the centre, as the rate of HIV is likely similar in those who are screened for hCG without chemotherapy.
Article Abstract
Objective: To assess the HIV prevalence in patients diagnosed with gestational trophoblastic neoplasia (GTN).
Design: A retrospective single centre cohort study.
Methods: A database from the Sheffield Trophoblastic Disease Centre (STDC), Sheffield, UK was searched between 1st January 2015 and 31st December 2021. A total of 3,591 patients were referred to STDC with a diagnosis of gestational trophoblastic disease (GTD), of which 221 (6.2%) were treated for GTN. The prevalence of HIV-positive tests in GTN patients was assessed.
Results: HIV testing was performed in 93% GTN patients ( n = 205/221). Overall, 1.3% of GTN patients ( n = 3/221) were HIV-positive, involving two known HIV-positive patients and one new diagnosis. This equates to a HIV prevalence of 14 : 1000, which is ∼7 to 9× higher than the HIV prevalence in Sheffield (1.9 per 1000) and Yorkshire and Humber (1.5 per 1000).
Conclusion: Given the extremely high HIV prevalence in our population, 'opt out' HIV testing is recommended within our specialist trophoblastic centre for all referred GTD and GTN patients. There is little reason to suspect that the prevalence of HIV-positive patients is any lower in the cohort of GTD patients referred to specialist trophoblastic centres for hCG screening alone, without requiring chemotherapy, particularly considering that most GTN arises from GTD.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/QAD.0000000000003738 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Metabolic Syndrome and Associated Factors Among People Living With HIV on Dolutegravir-Based Antiretroviral Therapy in Northern Tanzania.
J Int Assoc Provid AIDS Care
December 2024
Department of Internal Medicine, Kilimanjaro Christian Medical University College, Moshi, Tanzania.
Purpose: Chronic systemic inflammation from human immunodeficiency virus (HIV) may cause metabolic abnormalities in lipid metabolism. Additionally, the development of metabolic syndrome has been associated with specific anti-retroviral therapy, particularly dolutegravir. This study aimed to determine the prevalence and associated factors of metabolic syndrome among people living with HIV on dolutegravir-based anti-retroviral therapy.
View Article and Find Full Text PDFOral human papillomavirus infection and genotyping in a cohort of people living with HIV.
J Immunoassay Immunochem
December 2024
Department of Oral Medicine and Oral Pathology, Obafemi Awolowo University, Ile-Ife, Nigeria.
This study is aimed at determining the prevalence of oral HPV infection and the risk indicators for oral HPV carriage in people living with HIV. Data on socio-demographics, sexual behavioral practices, and lifestyle practices of the participants were collected from 66 people living with HIV. The HIV parameters of each study participant were obtained from clinical records.
View Article and Find Full Text PDFThe Impacts and Consequences of Sexually Transmitted Infections in the United States.
Sex Transm Dis
December 2024
Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Millions of people in the United States are affected by sexually transmitted infections (STIs) every year, with profound consequences for the individual, their community, and society at large. In this review, we aim to summarize the epidemiology of four STIs: C. trachomatis, N.
View Article and Find Full Text PDFEstimates of HIV Incidence, Prevalence, and Mortality in China 2018.
J Med Virol
December 2024
National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
A thorough and precise comprehension understanding of the HIV epidemic is crucial for effective HIV prevention and control. This study aimed to update the estimates of the overall HIV burden in China in 2018 and to assess the trends of HIV prevalence, incidence, and mortality from 1985 to 2018. The Estimation and Projection Package (EPP)/Spectrum software was utilized for estimation, a method highly recommended by UNAIDS.
View Article and Find Full Text PDFNon-alcoholic fatty liver disease among people living with HIV on long-term antiretroviral therapy in Indonesia: Prevalence and related factors.
SAGE Open Med
December 2024
Faculty of Medicine, Department of Internal Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
Background/objectives: As people with human immunodeficiency virus experience longer life expectancy, other causes of morbidity and mortality are being increasingly identified. The incidence of non-alcoholic fatty liver disease has recently been on the rise in Indonesia. People with human immunodeficiency virus on antiretroviral therapy are also at an increased risk of having non-alcoholic fatty liver disease.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!