Background And Objectives: One of the key aspects in the surgical technique of endoscopic third ventriculostomy (ETV) is the perforation of the floor of the third ventricle because of the high risk of injuring vital structures located in that region. According to the standard technique, this perforation should be performed in the midline halfway between mammillary bodies and the infundibular recess to avoid damage to the structures. This can be performed without excessive complications when the diameter of the prepontine cistern is wide. However, in situations where the diameter is reduced (defined in the literature as having a prepontine interval [PPI] ≤1 mm), the probability of complications increases exponentially.In this article, we propose using dorsum sellae as a key point to safely perform ETV in patients with a decreased PPI, guiding the trajectory and its marking using neuronavigation.
Methods: A review was conducted on the latest 100 ETV procedures performed by our team in the past 5 years. The measurement of the PPI was conducted using archived preoperative MRI imaging studies, specifically between the dorsum sellae and the basilar artery. In cases where the PPI was ≤1 mm and, therefore, the use of the dorsum sellae was applied as a reference point, the technical results and procedural functions were documented.
Results: In the cohort, 7 patients with a PPI ≤1 mm were identified. In all 7 cases, fenestration of the tuber cinereum was successfully performed without causing vascular damage or associated complications. ETV was successful in 6 patients, with only one experiencing ETV failure necessitating the placement of a ventriculoperitoneal shunt.
Conclusion: The utilization of the dorsum sellae as a reference point to perform ETV in reduced PPI constitutes a safe alternative to the classical technique.
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http://dx.doi.org/10.1227/ons.0000000000000930 | DOI Listing |
Sci Rep
January 2025
Department of Neurosurgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.
Transcription factors (TFs), including steroidogenic factor-1 (SF-1), T-box transcription factor (TPIT) and pituitary transcription factor-1 (PIT-1), play a pivotal role in the cytodifferentiation of adenohypophysis. However, the impact of TFs on the growth patterns of nonfunctioning pituitary adenomas (NFPAs) remains unclear. This study aims to investigate the correlation between the expression of TFs and NFPAs growth patterns.
View Article and Find Full Text PDFJ Craniomaxillofac Surg
December 2024
Department of Oral and Maxillofacial Surgery, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Republic of Korea. Electronic address:
This study assessed the accuracy and reliability of artificial intelligence (AI)-reconstructed images of two-dimensional (2D) lateral cephalometric analyses of facial computed tomography (CT) images, which is widely used for the diagnosis of craniofacial deformities and in the planning of their treatment. Facial CT datasets from 40 patients were collected. Original 1 mm slices were reformatted to 3 mm, and then an AI algorithm reconstructed the 3 mm slices and converted them back to 1 mm to generate lateral cephalometric images.
View Article and Find Full Text PDFFuture Oncol
November 2024
Department of Clinical Development, SELLAS Life Sciences Group, Inc., New York, NY, USA.
Patients with relapsed or refractory (r/r) acute myeloid leukemia (AML) have very poor long-term outcomes. Allogeneic stem cell transplantation (allo-SCT) can potentially cure some of these patients who are able to achieve a second or greater remission with salvage chemotherapy. Unfortunately, several barriers exist to transplantation and not all patients with r/r AML are able to proceed to allo-SCT.
View Article and Find Full Text PDFJ Craniofac Surg
October 2024
Department of Anatomy, Faculty of Medicine, Gaziantep University, Gaziantep.
Objective: To determine the dimension of the dorsum sellae (DS) in fetuses.
Methods: Skull bases of 32 fetuses aged from 17 to 32 weeks were included in the work. The length of the DS at its superior border (DSL-SB) and the thickness of DS at its middle part (DST-ML) were measured.
J Craniofac Surg
November 2024
Department of Anatomy, Faculty of Medicine, Gaziantep University, Gaziantep, Türkiye.
Objective: This study aims to assess the relation of the pituitary gland height (PGH) with the heights of the tuberculum sellae (TSH) and dorsum sellae (DSH) in adult patients with Chiari malformation type 1 (CM1).
Methods: Magnetic resonance imaging (MRI) views of 50 CM1 patients aged 20 to 71 years and 50 controls aged 20 to 65 years were included in the study.
Results: CM1 patients (6.
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