AI Article Synopsis
- - AFF4 is a scaffold protein in the superelongation complex (SEC), playing a crucial role as a transcription elongation factor that influences HIV activation, replication, and stem cell differentiation.
- - This protein is linked to the progression of various cancers, including head and neck squamous cell carcinoma, leukemia, and breast cancer, by regulating key transcription factors and interacting with other proteins involved in cellular processes.
- - The mini-view discusses the potential of targeting AFF4 for therapeutic purposes in treating AIDS and various cancers, as well as its role in maintaining stem cell characteristics.
Article Abstract
As a member of the AF4/FMR2 (AFF) family, AFF4 is a scaffold protein in the superelongation complex (SEC). In this mini-view, we discuss the role of AFF4 as a transcription elongation factor that mediates HIV activation and replication and stem cell osteogenic differentiation. AFF4 also promotes the progression of head and neck squamous cell carcinoma, leukemia, breast cancer, bladder cancer and other malignant tumors. The biological function of AFF4 is largely achieved through SEC assembly, regulates SRY-box transcription factor 2 (SOX2), MYC, estrogen receptor alpha (ESR1), inhibitor of differentiation 1 (ID1), c-Jun and noncanonical nuclear factor-κB (NF-κB) transcription and combines with fusion in sarcoma (FUS), unique regulatory cyclins (CycT1), or mixed lineage leukemia (MLL). We explore the prospects of using AFF4 as a therapeutic in Acquired immunodeficiency syndrome (AIDS) and malignant tumors and its potential as a stemness regulator.
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| http://dx.doi.org/10.2174/0113862073241079230920082056 | DOI Listing |
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