Quinoline and acyl thiourea scaffolds have major chemical significance in medicinal chemistry. Quinoline-based acyl thiourea derivatives may potentially target the urease enzyme. Quinoline-based acyl thiourea derivatives - were synthesized and tested for urease inhibitory activity. 19 derivatives (-) showed enhanced urease enzyme inhibitory potential (IC = 1.19-18.92 μM) compared with standard thiourea (IC = 19.53 ± 0.032 μM), whereas compounds - were inactive. Compounds with OCH, OCH, Br and CH on the aryl ring showed significantly greater inhibitory potential than compounds with hydrocarbon chains of varying length. Molecular docking studies were conducted to investigate ligand interactions with the enzyme's active site. The identified hits can serve as potential leads against the drug target urease in advanced studies.
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