AI Article Synopsis
- The study investigated how intracranial arteriosclerosis affects the risk of developing dementia in a group of 2,339 stroke- and dementia-free participants, averaging 69.5 years old.
- Over a follow-up period of about 13.4 years, it was found that both calcification in the carotid artery (ICAC) and vertebrobasilar artery (VBAC) were linked to a higher risk of dementia.
- The research indicated that the association between arteriosclerosis and dementia partly operates through increased cerebral small vessel disease (cSVD).
Article Abstract
Background: The impact of intracranial arteriosclerosis on dementia remains largely unclear.
Methods: In 2339 stroke-free and dementia-free participants (52.2% women, mean age 69.5 years) from the general population, we assessed intracranial carotid artery calcification (ICAC) and vertebrobasilar artery calcification (VBAC) as proxy for arteriosclerosis. Associations with dementia were assessed using Cox models. In addition, indirect effects through cerebral small vessel disease (cSVD) and subcortical brain structure volumes were assessed using causal mediation analyses.
Results: During a median of 13.4 years (25th-75th percentiles 9.9-14.5) of follow-up, 282 participants developed dementia. Both ICAC presence (hazard ratio [HR]: 1.53, 95% confidence interval [CI]: 1.00-2.32]) and volume (HR per standard deviation: 1.19, 95% CI: 1.01-1.40) increased dementia risk. For VBAC, severe calcifications increased dementia risk (HR for third vs first volume tertile: 1.89, 95% CI: 1.00-3.59). These effects were mediated partly through increased cSVD (percentage mediated for ICAC: 13% and VBAC: 24%).
Discussion: Intracranial arteriosclerosis increases the risk of dementia.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10916985 | PMC |
| http://dx.doi.org/10.1002/alz.13496 | DOI Listing |
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