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Mycophenolate Mofetil Appears Effective for the Treatment of Patients With Refractory Crohn's Disease.
Crohns Colitis 360
October 2024
Division of Gastroenterology, University of Washington, Seattle, WA, USA.
Background: Medically refractory Crohn's disease (CD) is associated with a high risk of complications. Mycophenolate mofetil (MMF), a small molecule immunosuppressant, has limited data in patients with CD, and objective endoscopic response to MMF has not been reported.
Aims: We evaluated the safety and clinical, endoscopic, and biochemical effectiveness of off-label MMF for refractory CD as monotherapy or in combination with a biologic in patients with CD.
Nurse practitioner program enrollment trends and predictions.
J Prof Nurs
December 2024
National Organization of Nurse Practitioner Faculties, United States of America.
Background: As the fastest growing segment of the healthcare workforce, understanding NP enrollment is vital.
Purpose: This work aimed to guide healthcare workforce forethought, academic planning, and policy initiatives.
Method: This secondary data analysis investigated nurse practitioner (NP) program enrollment trends from 2013 to 2022, including sub-analyses of master's versus doctoral enrollment, clinical tracks (acute care, primary care, psychiatric mental health), and enrollment status (part-time vs.
DNA tetrahedron nanoparticles service as a help carrier and adjvant of mRNA vaccine.
J Transl Med
November 2024
Department of Stomatology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Aim Of The Study: To investigate the potential of DNA nanoparticles (DNPs) as carriers and adjuvants for mRNA vaccines.
Materials And Methods: Customized oligonucleotides were assembled into DNA tetrahedra (DNA-TH), which were subsequently complexed with streptavidin and mRNA encoding green fluorescent protein (GFP). Various assays were conducted to evaluat the stability of the DNPs, their cellular uptake, immune activation potential, and GFP mRNA transcription efficiency.
Solid-state NMR compositional analysis of sputum from people with cystic fibrosis.
Solid State Nucl Magn Reson
December 2024
Department of Chemistry, Washington University, St. Louis, MO, 63130, United States. Electronic address:
People with the genetic disease cystic fibrosis (CF) often have chronic airway infections and produce airway secretions called sputum. A better understanding of sputum composition is desired in order to track changes in response to CF therapeutics and to improve laboratory models for the study of CF airway infections. The glycosylated protein mucin is a primary component.
View Article and Find Full Text PDFModeling and characterization of pure and odorant mixture processing in the mushroom body calyx.
Front Physiol
October 2024
Department of Computer and Information Science, Fordham University, New York, NY, United States.
Associative memory in the Mushroom Body of the fruit fly brain depends on the encoding and processing of odorants in the first three stages of the Early Olfactory System: the Antenna, the Antennal Lobe and the Mushroom Body Calyx. The Kenyon Cells (KCs) of the Calyx provide the Mushroom Body compartments the identity of pure and odorant mixtures encoded as a train of spikes. Characterizing the code underlying the KC spike trains is a major challenge in neuroscience.
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