Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.7326/M23-2299 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Two-Layer Retrieval-Augmented Generation Framework for Low-Resource Medical Question Answering Using Reddit Data: Proof-of-Concept Study.
J Med Internet Res
January 2025
Department of Biomedical Informatics, School of Medicine, Emory University, Atlanta, GA, United States.
Background: The increasing use of social media to share lived and living experiences of substance use presents a unique opportunity to obtain information on side effects, use patterns, and opinions on novel psychoactive substances. However, due to the large volume of data, obtaining useful insights through natural language processing technologies such as large language models is challenging.
Objective: This paper aims to develop a retrieval-augmented generation (RAG) architecture for medical question answering pertaining to clinicians' queries on emerging issues associated with health-related topics, using user-generated medical information on social media.
Managing xylazine-involved overdoses in a community harm reduction setting: lessons from Tijuana, Mexico.
Harm Reduct J
January 2025
Asociación Bajacaliforniana de Salud Pública A.C, Tijuana, Baja California, Mexico.
Background: Xylazine is a α2-adrenergic receptor agonist, used for sedation in veterinary contexts. Although it is increasingly found in overdose deaths across North America, the clinical management of xylazine-involved overdoses has not been extensively studied, especially in community-based harm reduction settings. Here we present a clinical series of xylazine-involved overdose and share the clinical approach and lessons learned by a community overdose response team in Tijuana, Mexico amidst the arrival of xylazine.
View Article and Find Full Text PDFFirst Detection of Xylazine in Texas Wastewater and Its Association with Fentanyl Use.
medRxiv
November 2024
Department of Environmental and Occupational Health Sciences, University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA.
Article Synopsis
- The United States is facing a worsening drug overdose crisis, with xylazine—an animal sedative—emerging as a significant threat in the illicit drug market.
- A study in El Paso, Texas, used wastewater analysis to monitor xylazine presence and its potential link to fentanyl use over 14 months, finding xylazine in most treatment plants sampled.
- The research indicated a direct correlation between xylazine and higher fentanyl levels, urging the need for improved monitoring and targeted health interventions in communities impacted by the opioid epidemic.
Rational hapten design, antibody preparation, and immunoassay development for rapid screening xylazine in biological samples.
Food Chem
February 2025
National Key Laboratory of Veterinary Public Health and Safety, Beijing Key Laboratory of Detection Technology for Animal Derived Food Safety, College of Veterinary Medicine, China Agricultural University, Beijing 100193, People's Republic of China; Technology Innovation Center for Food Safety Surveillance and Detection (Hainan), Sanya Institute of China Agricultural University, Sanya 572025, People's Republic of China. Electronic address:
Xylazine (XYL) is an illicit adulterant in opioids and an approved veterinary sedative drug, which has been abused, misused, and residued in food samples, endangering people health, causing drug-facilitated crimes and even death. Immunoassay used antibody as core biomaterial could to achieve highly sensitive and rapid detection screening purpose for XYL in situ. Here, we rationally designed four novel XYL haptens with different spacer arms to produce antibodies with high affinity and specificity.
View Article and Find Full Text PDFExperiences of the changing illicit drug supply among racial and ethnic minoritized people in three US states: a qualitative study.
Harm Reduct J
November 2024
Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Background: Amidst a national surge in overdose deaths among racial and ethnic minoritized people and people who use stimulants (cocaine or methamphetamines), our objective was to understand how these groups are adapting to a rapidly changing illicit drug supply.
Methods: We conducted semi-structured interviews with 64 people who use drugs and who self-identified as Black, Hispanic, Multiracial, or other Non-White race in three states (Michigan, New Jersey, and Wisconsin). Transcribed interviews were coded thematically.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!