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Synthesis of aminomethyl linked (+)-usnic acid derivatives the Mannich reaction and evaluation of their biological activities. | LitMetric
(+)-Usnic acid (UA), a natural dibenzofuran derivative, abundantly produced by lichens and possess wide number of biomedical applications including antibacterial, anti-inflammatory, anti-oxidant and anticancer activities. In the present study, as series of usnic acid derivatives () were synthesised using Mannich reaction assessed for their antioxidant, α-glucosidase, and anticancer activities. The antioxidant activity showed that compound displayed potent antioxidant activity by scavenging the activities of DPPH and ABTS. The compounds and showed potent cytotoxic activity against HepG2 cancer cells by arresting the cell cycle at S phase and regulating the Bax/BcL2 expression and subsequently induce the apoptosis. Overall, the results clearly indicated that (+)-usnic acid derivatives bearing secondary amines are useful scaffolds for the development of drug candidates for treatment of oxidative stress mediated cancer and metabolic disorders.
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