AI Article Synopsis
- - The text discusses a type of bacteria that leads to severe hospital and community infections, often showing resistance to multiple drugs worldwide.
- - These infections are linked to factors like antibiotic use and weakened immune systems, yet the specific genetic features that contribute to their ability to cause disease are not well understood.
- - Research indicates that genetic changes in these bacteria can influence infection rates in both hospital and non-hospital settings and may be connected to how they can move from the gut to the bloodstream, with host and environmental factors, like gut microbiota, playing a significant role.
Article Abstract
causes life-threatening invasive hospital- and community-associated infections that are usually associated with multidrug resistance globally. Although infections cause opportunistic infections typically associated with antibiotic use, immunocompromised immune status, and other factors, they also possess an arsenal of virulence factors crucial for their pathogenicity. Despite this, the relative contribution of these virulence factors and other genetic changes to the pathogenicity of strains remain poorly understood. Here, we investigated whether specific genomic changes in the genome of isolates influence its pathogenicity-infection of hospitalized and nonhospitalized individuals and the propensity to cause extraintestinal infection and intestinal colonization. Our findings indicate that genetics partially influence the infection of hospitalized and nonhospitalized individuals and the propensity to cause extraintestinal infection, possibly due to gut-to-bloodstream translocation, highlighting the potential substantial role of host and environmental factors, including gut microbiota, on the opportunistic pathogenic lifestyle of this bacterium.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10714801 | PMC |
| http://dx.doi.org/10.1128/spectrum.00201-23 | DOI Listing |
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