AI Article Synopsis
- The report details a method for Pd-catalyzed decarbonylative coupling, using difluorobenzyl glutarimides and (hetero)aryl boronate esters to create new difluorobenzyl-substituted (hetero)arene compounds.
- The phosphine ligand PAdBu and neopentylboronate ester nucleophiles are crucial for achieving selective product formation, specifically avoiding the production of difluorobenzyl ketones.
- This coupling reaction is applicable to a wide range of (hetero)aryl boronate esters and difluorobenzyl glutarimides, demonstrating its versatility.
Article Abstract
This report describes the Pd-catalyzed decarbonylative coupling of difluorobenzyl glutarimides with (hetero)aryl boronate esters to yield difluorobenzyl-substituted (hetero)arene products. The use of PAdBu as the phosphine ligand in combination with neopentylboronate ester nucleophiles proved critical for the selective formation of the decarbonylative coupling product versus analogous difluorobenzyl ketone. This transformation is effective for electronically diverse (hetero)aryl boronate esters and substituted difluorobenzyl glutarimides.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10629228 | PMC |
| http://dx.doi.org/10.1021/acs.orglett.3c03071 | DOI Listing |
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