AI Article Synopsis
- The COVID-19 pandemic's management included global vaccination, but concerns arose about antibody decline following various vaccines.
- A study investigated the effectiveness of the PastoCovac Plus protein subunit booster in healthcare workers who had been vaccinated with COVAXIN, highlighting the need for boosters at least three months after the second dose.
- The findings revealed significant increases in neutralizing and anti-Spike antibodies, but a notable percentage of participants remained seronegative for these antibodies, underscoring the importance of booster vaccinations to combat variants like Delta.
Article Abstract
COVID-19 pandemic has been managed through global vaccination programs. However, the antibody waning in various types of vaccines came to notice. Hereby, PastoCovac Plus as a protein subunit vaccine was investigated in immunized health care workers by COVAXIN (BBV152). The booster vaccine was recommended at least three months post the second dose of COVAXIN. Sera collection was done before and after each injection. SARS-CoV-2 PCR test was done monthly to detect any asymptomatic and symptomatic vaccine breakthrough. 47.9 and 24.3% of the participants were seronegative for anti-N and anti-S antibodies three months after the second dose of COVAXIN, respectively. On average, fold-rises of 70, 93, 8 and mean-rises of 23.32, 892.4, 5.59 were recorded regarding neutralizing antibody, quantitative and semi-quantitative anti-Spike antibody, respectively. Anti-Spike and neutralizing antibodies seroconversion was seen 59.3% and 45.7%, respectively. The vaccine breakthrough assessment showed that all the isolated samples belonged to SARS-CoV-2 Delta variant. PastoCovac Plus boosting is strongly recommended in combination with inactivated vaccine platforms against SARS-CoV-2.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10551543 | PMC |
| http://dx.doi.org/10.1016/j.heliyon.2023.e20555 | DOI Listing |
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