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| http://dx.doi.org/10.1016/j.opresp.2023.100247 | DOI Listing |
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Pulmonary and systemic effects of inhaled crystalline silica in the HOCl-induced mouse model of systemic sclerosis: An experimental model of Erasmus syndrome.
Clin Immunol
February 2025
Univ Rennes, INSERM, EHESP, IRSET (Institut de recherche en santé, environnement et travail) - UMR_S 1085, F-35000 Rennes, France. Electronic address:
Occupational exposure to crystalline silica is etiologically linked to an increased incidence of systemic sclerosis (SSc), also called Erasmus syndrome. The underlying mechanisms of silica-related SSc are still poorly understood. We demonstrated that early and repeated silica exposure contribute to the severity of SSc symptoms in the hypochloric acid (HOCl)-induced SSc mouse model.
View Article and Find Full Text PDF[5 cases of silicosis complicated with connective tissue diseases].
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
March 2024
Department of Occupational Disease, the Third People's Hospital of Yunnan Province, Kunming 650011, China.
Long-term inhalation of silica dust can cause silicosis, but also may induce autoimmune diseases, such as systemic sclerosis, rheumatoid arthritis, systemic lupus erythematosus, Sjogren's syndrome, anti-histidyl tRNA synthetase antibody (JO-1 antibody) syndrome. These two diseases can be isolated or combined. In this paper, the clinical characteristics of 5 cases of silicosis complicated with connective tissue diseases were analyzed and summarized to strengthen the clinical understanding of silicosis complicated with connective tissue diseases, so as to reduce its misdiagnosis and missed diagnosis, and provide reference for clinicians in diagnosis and treatment.
View Article and Find Full Text PDFSystemic sclerosis, silica exposure and cellular therapies: The sand in the gears?
Rev Med Interne
July 2024
Unité de médecine interne (UF04): CRMR MATHEC, maladies auto-immunes et thérapie cellulaire, centre de référence des maladies auto-immunes systémiques rares d'Île-de-France, recherche clinique en hématologie, immunologie et transplantation, URP3518, hôpital St-Louis, AP-HP, université Paris Cité, IRSL, 75010 Paris, France; Department of Medicine, McGill University, H3A 1A1 Montreal, Canada.
Systemic sclerosis (SSc) is a chronic orphan autoimmune disease with the highest mortality rate among rheumatic diseases. SSc-related interstitial-lung disease (ILD) remains among the leading causes of SSc-related mortality with still few therapeutic effective strategies. In patients with crystallin silica exposure, SSc is recognized as an occupational disease according to the French social security system (Table 25A of the general insurance regimen).
View Article and Find Full Text PDFAssociation between silicosis and autoimmune disease.
Curr Opin Allergy Clin Immunol
April 2024
Pulmonary Division, Lady Davis Carmel Medical Center, Faculty of Medicine Technion Institute of Technology, Haifa, Israel.
Article Synopsis
- Silica inhalation is linked to autoimmune diseases, and recent findings highlight new sources of exposure from industries like jewelry polishing and glass manufacturing, leading to a resurgence of silicosis globally.
- * Research suggests that long-term silica exposure may be a risk factor for autoimmune conditions such as scleroderma and rheumatoid arthritis, and the interaction with other factors may trigger immune system issues.
- * Understanding the mechanisms behind silica-induced autoimmune diseases could enhance early detection and treatment options for affected individuals.
[A rare case: Erasmus syndrome and tuberculosis].
Medicina (B Aires)
January 2024
Hospital de Rehabilitación Respiratoria María Ferrer, Buenos Aires, Argentina.
We present the case of a 35-year-old male patient, sandblaster for eight years, recently diagnosed with pulmonary tuberculosis and systemic sclerosis, who was admitted with dyspnea and poor general condition. Chest X-ray showed a grade I pneumothorax, and on the chest tomography he presented confluent hyperdense masses associated with a pattern of non- specific interstitial pneumonia (NSIP), findings compatible with complicated silicosis. Due to the advanced clinical stage, neither invasive diagnostic test nor pulmonary function test could be performed.
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