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| http://dx.doi.org/10.3389/fpls.2023.1290281 | DOI Listing |
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Inflammation subsequent to mild iron excess differentially alters regional brain iron metabolism, oxidation and neuroinflammation status in mice.
Front Aging Neurosci
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Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
Iron dyshomeostasis and neuroinflammation, characteristic features of the aged brain, and exacerbated in neurodegenerative disease, may induce oxidative stress-mediated neurodegeneration. In this study, the effects of potential priming with mild systemic iron injections on subsequent lipopolysaccharide (LPS)-induced inflammation in adult C57Bl/6J mice were examined. After cognitive testing, regional brain tissues were dissected for iron (metal) measurements by total reflection X-ray fluorescence and synchrotron radiation X-Ray fluorescence-based elemental mapping; and iron regulatory, ferroptosis-related, and glia-specific protein analysis, and lipid peroxidation by western blotting.
View Article and Find Full Text PDFcharacterization of novel hyaluronan-antioxidant conjugates as potential topical therapeutics against hearing loss.
Front Pharmacol
February 2024
Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, MT, United States.
Noise-induced hearing loss affects roughly 430 million people worldwide. Current treatment options often require invasive medical procedures, and to date, there are no FDA-approved drug therapies. While the causes can be diverse, noise induced hearing loss is unequivocally associated with oxidative stress and inflammation, and subsequent damage to the inner ear structures.
View Article and Find Full Text PDFEditorial: Stress-mediated regulation of plant specialized metabolism.
Front Plant Sci
September 2023
Department of Botany, School of Life Sciences, Central University of Jammu, Samba, Jammu and Kashmir, India.
Nrf2 as a Potential Therapeutic Target for Traumatic Brain Injury.
J Integr Neurosci
June 2023
Laboratory of CNS Injury and Molecular Therapy, JFK Neuroscience Institute, Hackensack Meridian JFK University Medical Center, Edison, NJ 08820, USA.
In this review, we discuss the possibility and feasibility of nuclear factor erythroid 2-related factor 2 (Nrf2) as a therapeutic target to minimize the devastating effects of a brain injury. To complete this review, comprehensive literature searches were conducted in MEDLINE, PubMed, Embase, and PsycINFO databases for English scientific peer-reviewed articles through December 2022. This short review addressed the different sources of oxidative stress and its effects on blood-brain barrier (BBB) dysfunction, mitochondrial damage, and changes in a variety of inflammatory molecules associated with central nervous system (CNS) injury.
View Article and Find Full Text PDFRelationship between plasma Neuregulin-1 and cardiac function in patients with ST-elevation myocardial infarction.
Rev Cardiovasc Med
February 2022
Center for Biomedical Research, Medical University of Vienna, 1090 Vienna, Austria.
Background: Neuregulin-1 (NRG-1) is a stress-mediated transmembrane growth factor. Reduced myocardial damage and higher NRG-1 levels upon treatment with remote ischemic conditioning (RIC) has been described in rats. However, the role of NRG-1 in patients with acute myocardial infarction (MI) is unknown.
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