Communication and information technologies shape the world's systems of today, and those systems shape our society. The security of those systems relies on mathematical problems that are hard to solve for classical computers, that is, the available current computers. Recent advances in quantum computing threaten the security of our systems and the communications we use. In order to face this threat, multiple solutions and protocols have been proposed in the Post-Quantum Cryptography project carried on by the National Institute of Standards and Technologies. The presented work focuses on defining a formal framework in Maude for the security analysis of different post-quantum key encapsulation mechanisms under assumptions given under the Dolev-Yao model. Through the use of our framework, we construct a symbolic model to represent the behaviour of each of the participants of the protocol in a network. We then conduct reachability analysis and find a man-in-the-middle attack in each of them and a design vulnerability in Bit Flipping Key Encapsulation. For both cases, we provide some insights on possible solutions. Then, we use the Maude Linear Temporal Logic model checker to extend the analysis of the symbolic system regarding security, liveness and fairness properties. Liveness and fairness properties hold while the security property does not due to the man-in-the-middle attack and the design vulnerability in Bit Flipping Key Encapsulation.
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http://dx.doi.org/10.7717/peerj-cs.1547 | DOI Listing |
Vet Res
January 2025
College of Veterinary Medicine, Northeast Agricultural University, Harbin, China.
Avian coccidiosis, caused by the protozoan Eimeria, leads to significant economic losses for the poultry industry. In this study, bacteriophages that specifically bind to the calcium-binding protein (EtCab) of Eimeria tenella were selected using a biopanning process with a pIII phage display library. The recombinant EtCab protein served as the ligand in this selection process.
View Article and Find Full Text PDFJ Cancer Res Clin Oncol
January 2025
Phase I Clinical Trial Centre, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Purpose: The primary objectives of this trial were aimed at exploring the pharmacokinetic profiles and the human bioequivalence of an intravenous liposomal injection of doxorubicin hydrochloride in comparison with a reference formulation in Chinese patients diagnosed with metastatic breast cancer.
Methods: To achieve these goals, the trial employed a randomized, open-label, two-formulation crossover dosing strategy among Chinese patients with metastatic breast cancer. Pharmacokinetic (PK) evaluation was conducted through the collection of blood samples, and the liquid chromatography tandem mass spectrometry (LC/MS/MS) method was leveraged to quantify plasma concentrations of both liposome-encapsulated doxorubicin and non-encapsulated doxorubicin in patients.
Int J Pharm
January 2025
Department of Pharmaceutics, College of Pharmacy, Chongqing Medical University, Chongqing 400016 China. Electronic address:
Loading drug-maleimide (MAL) conjugates into liposomes preloaded with glutathione (GSH) can prepare the liposome encapsulating GSH-conjugated prodrugs, which serve as a feasible way to construct liposomal formulation. However, the effects ofthelinker on the development of this liposomal system remained unclear. Herein, docetaxel (DTX)-MAL conjugates linked by various linkers were used for such studies.
View Article and Find Full Text PDFClin Imaging
January 2025
The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
All of us must find the right balance between team science and fostering leadership with dynamic colleagues. That dichotomy was well-encapsulated in a famous exchange between basketball players Shaquille O'Neal and Kobe Bryant regarding there "being no 'I' in team". In our view, there is nothing more satisfying than collaborating with a team of people and publishing impactful papers or making key discoveries.
View Article and Find Full Text PDFAdv Sci (Weinh)
January 2025
School of Inspection, Ningxia Medical University, Yinchuan, Ningxia, 750004, China.
Sepsis is a severe systemic inflammatory syndrome characterized by a dysregulated immune response to infection, often leading to high mortality rates. The intestine, owing to its distinct structure and physiological environment, plays a pivotal role in the pathophysiology of sepsis. It functions as the "central organ" or "engine" in the progression of sepsis, with intestinal injury exacerbating the condition.
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