AI Article Synopsis

  • Azole drugs are losing effectiveness against Vulvovaginal Candidiasis (VVC) and Recurrent VVC due to antifungal resistance, prompting research into alternative treatments like silver nanoparticles (AgNPs).
  • The study developed a vaginal cream containing AgNPs and evaluated its antimicrobial activity, finding that AgNPs used in combination with miconazole significantly increased antifungal effectiveness.
  • Characterization of AgNPs indicated that those synthesized with certain amounts of sodium dodecyl sulfate (SDS) showed a promising size and stability, with the new cream outperforming commercial miconazole in inhibition zones despite having a lower concentration.

Article Abstract

The ineffectiveness of azole drugs in treating Vulvovaginal Candidiasis (VVC) and Recurrent Vulvovaginal Candidiasis (RVVC) due to antifungal resistance of non-albicans Candida has led to the investigation of inorganic nanoparticles with biological activity. Silver nanoparticles (AgNPs) are important in nanomedicine and have been used in various products and technologies. This study aimed to develop a vaginal cream and assess its in vitro antimicrobial activity against strains, specifically focusing on the synergy between AgNPs and miconazole. AgNPs were synthesized using glucose as a reducing agent and sodium dodecyl sulfate (SDS) as a stabilizer in varying amounts (0.50, 0.25, and 0.10 g). The AgNPs were characterized using UV-Visible (UV-Vis) and Fourier-Transform Infrared (FT-IR) spectroscopies, X-Ray Diffraction (XRD), Dynamic Light Scattering (DLS), Scanning Electron Microscopy (SEM), and Energy Dispersive X-Ray Analysis (EDX). Fifty strains of were used to evaluate the synergistic activity. AgNPs synthesized with 0.5 g SDS had an average size of 77.58 nm and a zeta potential of -49.2 mV, while AgNPs with 0.25 g showed 91.22 nm and -47.2 mV, respectively. AgNPs stabilized with 0.1 g of SDS were not effective. When combined with miconazole, AgNPs exhibited significant antifungal activity, resulting in an average increase of 80% in inhibition zones. The cream developed in this study, containing half the miconazole concentration of commercially available medication, demonstrated larger inhibition zones compared to the commercial samples.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10550885PMC
http://dx.doi.org/10.1007/s13205-023-03776-9DOI Listing

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