AI Article Synopsis
- This study is the first to investigate the significance of circulating bacterial DNA in patients with renal cell carcinoma (RCC).
- Researchers analyzed serum extracellular vesicles from 88 RCC patients and 10 healthy individuals, finding three types of bacterial DNA: Bacteroidia, TM7-1, and Sphingomonadales.
- A newly created BTS index, based on this bacterial DNA, effectively diagnosed RCC and indicated that higher levels of Bacteroidia DNA were linked to worse patient outcomes during nivolumab treatment.
Article Abstract
This is the first study to determine the clinical importance of circulating bacterial DNA in patients with renal cell carcinoma (RCC). We performed 16S rRNA metagenomic analysis of serum extracellular vesicles (EVs) from 88 patients with RCC and 10 healthy donors and identified three abundant bacterial DNA: Bacteroidia, TM7-1, and Sphingomonadales. Combining characteristic bacterial DNA information (three bacteria-derived DNA), a BTS index was created to diagnose patients with RCC. The BTS index showed high sensitivity not only in the discovery cohort, but also in the validation cohort, suggesting that it was useful as a screening test. Furthermore, in nivolumab treatment of RCC, patients with higher levels of Bacteroidia DNA in serum EVs had significantly poorer progression-free and overall survival than did those with lower levels. This study showed that circulating Bacteria-derived DNA could be used as a biomarker for RCC.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10559165 | PMC |
| http://dx.doi.org/10.1016/j.heliyon.2023.e19800 | DOI Listing |
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