This paper presents a novel use of the HOMER Software for the multi-year economic, environmental, and energetic assessment of a proposed multi-source standalone renewable microgrid. A rural-but-rapidly-commercializing community in Nigeria's middle belt was used as a case study, with an average power demand of 975 kW and average consumption of 23.028 MWh/day. A generation mix of flat-plate photovoltaic (PV) array (3 MW nominal), concentrated solar thermal (CSP, 9 MW nominal), and small hydropower (SH, up to 200 kW), with battery storage (200 strings), system converter (2.5 MW nominal) using the Oshin River was recommended as the optimal system for minimizing the cost of electricity (LCOE) in HOMER. A diesel-based system was also simulated and a multiyear analysis for a 25-year period shows that the Net Present Cost (NPC) of $55.7 million for the renewable microgrid is vastly superior to the $408 million for the diesel microgrid, with LCOE of $0.26 and $1.01 per kWh respectively. The system also saved up to 7540 metric tons of CO2 per year in emissions. The results of the study indicate the proposed microgrid as an economically and environmentally superior alternative to diesel generators in the long term, and as deserving consideration for similar applications.
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http://dx.doi.org/10.1016/j.heliyon.2023.e19189 | DOI Listing |
J Imaging Inform Med
January 2025
Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan.
Non-alcoholic fatty liver disease (NAFLD) is a highly prevalent chronic liver condition characterized by excessive hepatic fat accumulation. Early diagnosis is crucial as NAFLD can progress to more severe conditions like steatohepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma without timely intervention. While liver biopsy remains the gold standard for NAFLD assessment, abdominal ultrasound (US) imaging has emerged as a widely adopted non-invasive modality due to convenience and low cost.
View Article and Find Full Text PDFLung
January 2025
Advanced Lung Disease and Transplant Program, Inova Heart and Vascular Institute, Inova Fairfax Hospital, 3300 Gallows Road, Falls Church, VA, 22042, USA.
Purpose: Pulmonary hypertension (PH) is associated with morbidity and mortality in patients with interstitial lung disease (ILD). Several prediction models have been proposed to predict PH in ILD patients. We sought to discern how previously described prediction models perform in predicting PH in patients with ILD.
View Article and Find Full Text PDFJ Mater Chem B
January 2025
Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Lucknow, Uttar Pradesh, 226025, India.
This research demonstrates the design and development of a novel dual-targeting, pH-sensitive liposomal (pSL) formulation of 5-Fluorouracil (5-FU), , (5-FU-iRGD-FA-pSL) to manage breast cancer (BC). The motivation to explore this formulation is to overcome the challenges of systemic toxicity and non-specific targeting of 5-FU, a conventional chemotherapeutic agent. The proposed formulation also combines folic acid (FA) and iRGD peptides as targeting ligands to enhance tumor cell specificity and penetration, while the pH-sensitive liposomes ensure the controlled drug release in the acidic tumor microenvironment.
View Article and Find Full Text PDFJ Chem Theory Comput
January 2025
Institute of Physical Chemistry, RWTH Aachen University, Aachen 52074, Germany.
Exploring the conformational space of molecules remains a challenge of fundamental importance to quantum chemistry: identification of relevant conformers at ambient conditions enables predictive simulations of almost arbitrary properties. Here, we propose a novel approach, called TTConf, to enable conformational sampling of large organic molecules where the combinatorial explosion of possible conformers prevents the use of a brute-force systematic conformer search. We employ tensor trains as a highly efficient dimensionality reduction algorithm, effectively reducing the scaling from exponential to polynomial.
View Article and Find Full Text PDFRev Sci Instrum
January 2025
Shenyang Bluewisdom Technology Co., Ltd., Shenyang, Liaoning Province 110623, China.
Existing lower limb exoskeletons (LLEs) have demonstrated a lack of sufficient patient involvement during rehabilitation training. To address this issue and better incorporate the patient's motion intentions, this paper proposes an online brain-computer interface (BCI) system for LLE based motor imagery and stacked ensemble. The establishment of this online BCI system enables a comprehensive closed-loop control process, which includes the collection and decoding of brain signals, robotic control, and real-time feedback mechanisms.
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