Enhanced TrkA signaling impairs basal forebrain-dependent behavior.

Front Mol Neurosci

Department of Cell Biology and Pathology, Instituto de Neurociencias de Castilla y León (INCyL), Universidad de Salamanca, Salamanca, Spain.

Published: September 2023

AI Article Synopsis

  • Two different mouse models with TrkA deletion in the CNS had conflicting outcomes regarding BFCN function, prompting further investigation.
  • A mouse model with enhanced TrkA signaling showed increased cholinergic neuron development and ChAT expression, but resulted in impaired motor learning and memory, highlighting the need for balanced NGF/TrkA signaling in the central nervous system.

Article Abstract

Basal forebrain cholinergic neurons (BFCNs) modulate cognitive functions such as attention, learning and memory. The NGF/TrkA pathway plays an important role in the development and function of BFCNs, although two mouse models conditionally deleting TrkA expression in the central nervous system (CNS) have shown contradictory results. To shed light into this discrepancy, we used a mouse model with a gain-of-function in TrkA receptor signaling. Our results indicate that enhanced TrkA signaling did not alter hippocampal cholinergic innervation, general locomotion or anxiety-related behaviors, but it increases ChAT expression, the number of cholinergic neurons at early postnatal stages and, mutant mice showed impaired motor learning and memory functions. These data demonstrate that proper functioning of the cholinergic system in CNS requires a balanced NGF/TrkA signaling.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10556247PMC
http://dx.doi.org/10.3389/fnmol.2023.1266983DOI Listing

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