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Identification and characterization of murine glycoprotein 2-expressing intestinal dendritic cells. | LitMetric

The intestinal lamina propria (LP) contains distinct subsets of classical dendritic cells (cDC), each playing key non-redundant roles in intestinal immune homeostasis. Here, we show that glycoprotein 2 (GP2), a GPI-anchored protein and receptor for bacterial type-I fimbriae, is selectively expressed by CD103CD11b cDC in the murine small intestine (SI). GP2 expression was induced on CD103CD11b cDC within the SI-LP and was regulated by IRF4, TGFβR1- and retinoic acid signalling. Mice selectively lacking Gp2 on CD103CD11b cDC (huLang-Cre.gp2 mice) had normal numbers and proportions of innate and adaptive immune cells in the SI-LP suggesting that GP2 expression by CD103CD11b cDC is not required for intestinal immune homoeostasis.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9786990PMC
http://dx.doi.org/10.1111/sji.13219DOI Listing

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