The stability of the surrounding rock for the construction excavation and the reinforcement of the lining structure during operation in the water-rich area is a difficult problem for the design of high-head underground turnout pipes. Firstly, according to the mechanism of excavation load release and surrounding rock damage evolution, the seepage effect of excavation in the construction of the forked caves is coupled to the surrounding rock stress damage, and an iterative method of numerical simulation of the coupled mutual feedback effect of excavation surrounding rock stress and seepage is proposed. Then, based on the cracking characteristics of the high internal water pressure reinforced concrete turnpike lining, a numerical analysis method of the coupling interaction between lining cracking and internal water seepage is proposed by coupling internal water seepage to stress damage in the lining by cracking the forked pipe structure. Applying the aforementioned method to a forked pipe project, the results show that: during the construction period, there is a significant increase in the damage zone, stress, and displacement of the rock around the cavern after considering the coupled iterations; during the operation period, with the increase in internal water pressure, the lining structure accelerates cracking due to the external infiltration of internal water; after the internal water is applied, the surrounding rock bears the main internal water pressure and the reinforcement bears only part of the circumferential force. The method provides theoretical support for the analysis and calculation of the reinforcement of similar underground high-pressure tunnels for rock support and lining structures and has certain theoretical and engineering significance.
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http://dx.doi.org/10.1038/s41598-023-44148-w | DOI Listing |
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College of Sciences, College of Forestry, Henan Agricultural University, Zhengzhou 450002, China.
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NMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening & Guangdong-Hongkong-Macao Joint Laboratory for New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Compound 13b, a newly identified anthraquinone derivative, has demonstrated potent efficacy against the Zika virus. To explore the bioavailability and pharmacokinetic properties of compound 13b, a robust and sensitive HPLC-MS/MS method was established and verified to determine its plasma concentration in rats. Sample preparation involved protein precipitation using acetonitrile with testosterone as an internal standard.
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Guangxi Key Laboratory of Green Processing of Sugar Resources, College of Biological and Chemical Engineering, Guangxi University of Science and Technology, Liuzhou City 545006, Guangxi, PR China; Province and Ministry Co-Sponsored Collaborative Innovation Center of Sugarcane and Sugar Industry, Nanning 530004 Guangxi, PR China. Electronic address:
The problems of poor water solubility, poor stability, and poor selectivity encountered in the determination of hexavalent chromium (Cr(VI)) in water using ZnO QDs need to be addressed. In this study, we successfully prepared Sm-doped, -NH-modified Sm:ZnO-NH QDs via the sol-gel method. Sm doping was used to enhance the fluorescence intensity of ZnO QDs, while 3-aminopropyltrietoxysilane (APTEs) capping improved their water solubility and fluorescence stability.
View Article and Find Full Text PDFPlant Dis
March 2025
Beijing Academy of Agriculture and Forestry Sciences, Institute of plant protection, No. 9 of ShuGuangHuaYuan ZhongLu, Haidian District, Beijing 100097, China., Beijing, China, 100097;
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