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http://dx.doi.org/10.1016/j.jaad.2023.08.110DOI Listing

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Article Synopsis
  • - Palmoplantar pustulosis (PPP) is a painful chronic skin disorder affecting the palms and soles, with no approved treatments in Europe and the USA, although guselkumab is approved in Japan.
  • - A phase II study involving 50 Caucasian patients showed that administering 100 mg of guselkumab subcutaneously for 24 weeks significantly reduced the severity of PPP, with a median improvement of 59.6% in the PPP severity index.
  • - The study concluded that guselkumab could be a viable treatment option for Caucasian patients suffering from moderate-to-severe PPP, as indicated by substantial improvements in both clinical and quality of life measures.
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This month in JAAD International: January 2025: Guselkumab for palmoplantar pustulosis.

J Am Acad Dermatol

January 2025

Department of Dermatology, Center for Global Health, and Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania; Florida Center for Dermatology, St. Augustine, Florida. Electronic address:

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Warts are a prevalent skin condition that can affect people of any age. They are caused by the human papillomavirus (HPV), a double-stranded DNA virus that can cause benign and malignant lesions and remains latent in the host cells, leading to recurrences. Although warts are benign and spontaneous clearance has been reported over the years, they often cause disfigurement, tend to koebnerize, and can be transmitted to others, making adequate and timely treatment important.

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Introduction: Palmoplantar psoriasis is a rare variant of psoriasis. Its impact on quality of life has been poorly investigated.

Objectives: Our aim was to investigate the prevalence of localized palmoplantar psoriasis (PPP), to assess its severity using the modified Palmoplantar Pustular Psoriasis Area and Severity Index (m-PPPASI), and to evaluate the correlation with the Dermatology Life Quality Index (DLQI).

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