[Effect of viral infection on host cell metabolism: a review].

Sheng Wu Gong Cheng Xue Bao

Medical College, Kunming University of Science and Technology, Kunming 650500, Yunnan, China.

Published: September 2023

As specialized intracellular parasite, viruses have no ability to metabolize independently, so they completely depend on the metabolic mechanism of host cells. Viruses use the energy and precursors provided by the metabolic network of the host cells to drive their replication, assembly and release. Namely, viruses hijack the host cells metabolism to achieve their own replication and proliferation. In addition, viruses can also affect host cell metabolism by the expression of auxiliary metabolic genes (AMGs), affecting carbon, nitrogen, phosphorus, and sulfur cycles, and participate in microbial-driven biogeochemical cycling. This review summarizes the effect of viral infection on the host's core metabolic pathway from four aspects: cellular glucose metabolism, glutamine metabolism, fatty acid metabolism, and viral AMGs on host metabolism. It may facilitate in-depth understanding of virus-host interactions, and provide a theoretical basis for the treatment of viral diseases through metabolic intervention.

Download full-text PDF

Source
http://dx.doi.org/10.13345/j.cjb.220888DOI Listing

Publication Analysis

Top Keywords

host cells
12
viral infection
8
host cell
8
cell metabolism
8
metabolism
7
host
6
metabolic
5
[effect viral
4
infection host
4
metabolism review]
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!