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Metabolic phenotyping of BMI to characterize cardiometabolic risk: evidence from large population-based cohorts. | LitMetric

AI Article Synopsis

  • - Obesity increases the risk of type 2 diabetes and cardiovascular disease, but some individuals with normal BMI can still have these conditions, while not all obese people show metabolic issues, leading to the "metabolically healthy obese" concept.
  • - Researchers propose a new measure, the metabolic BMI score (mBMI), which reflects metabolic health more accurately than traditional BMI by identifying those at different risks for disease despite having similar body weights.
  • - Lifestyle changes such as exercise and diet can positively influence an individual’s mBMI, allowing for better identification of at-risk people who may benefit from targeted health interventions.

Article Abstract

Obesity is a risk factor for type 2 diabetes and cardiovascular disease. However, a substantial proportion of patients with these conditions have a seemingly normal body mass index (BMI). Conversely, not all obese individuals present with metabolic disorders giving rise to the concept of "metabolically healthy obese". We use lipidomic-based models for BMI to calculate a metabolic BMI score (mBMI) as a measure of metabolic dysregulation associated with obesity. Using the difference between mBMI and BMI (mBMIΔ), we identify individuals with a similar BMI but differing in their metabolic health and disease risk profiles. Exercise and diet associate with mBMIΔ suggesting the ability to modify mBMI with lifestyle intervention. Our findings show that, the mBMI score captures information on metabolic dysregulation that is independent of the measured BMI and so provides an opportunity to assess metabolic health to identify "at risk" individuals for targeted intervention and monitoring.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10560260PMC
http://dx.doi.org/10.1038/s41467-023-41963-7DOI Listing

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