AI Article Synopsis

  • Amyloidosis is a group of disorders where amyloid protein builds up in various tissues, causing functional issues.
  • A 70-year-old Japanese woman experienced left hydronephrosis due to a lower ureteral obstruction, leading to a suspicion of a tumor despite biopsies showing no malignancy.
  • After surgery to remove the affected section of her ureter, she was diagnosed with localized ureteral amyloidosis and remained free of recurrence for 9 months after the procedure.

Article Abstract

Background: Amyloidosis is a collection of disorders characterized by the extracellular deposition of amyloid, a specialized fibrous protein, in diverse tissues, leading to functional impairments.

Case Presentation: A 70-year old Asian-Japanese female was referred to our department for further examination of her left hydronephrosis come from lower ureteral obstruction. Contrast enhanced CT and retrograde pyelo-nephrography revealed left ureteral tumor. Though ureteroscropic biopsy did not show malignant pathological findings, ureteroscopic image suspected malignant disease, thus nephroureterectomy was performed. Pathological findings revealed localized ureteral amyloidosis. Whole body examination including gastro endoscopy and cardio ultrasonography could not reveal amyloidosis except ureter. She was free from recurrence 9 months postoperatively.

Conclusion: We herein report a rare case of localized ureteral amyloidosis.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10560414PMC
http://dx.doi.org/10.1186/s13256-023-04138-yDOI Listing

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  • Amyloidosis is a group of disorders where amyloid protein builds up in various tissues, causing functional issues.
  • A 70-year-old Japanese woman experienced left hydronephrosis due to a lower ureteral obstruction, leading to a suspicion of a tumor despite biopsies showing no malignancy.
  • After surgery to remove the affected section of her ureter, she was diagnosed with localized ureteral amyloidosis and remained free of recurrence for 9 months after the procedure.
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Ureteral amyloidosis is a rare entity and of interest to urologists, hematologists, radiologists, and pathologists because it mimics urothelial cell carcinoma clinically, endoscopically and radiologically. A pre-operative ureteroscopy or surgical biopsy is required, and it is essential to exclude systemic amyloidosis. We report a male who was diagnosed with IIIA stage lymphoplasmacytic lymphoma associating systemic amyloidosis with concomitant hematuria.

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