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Persistence of Oropouche virus in body fluids among imported cases in France, 2024.
Lancet Infect Dis
December 2024
IHU-Méditerranée Infection, Marseille, France; Aix Marseille Université, AP-HM, MEPHI, Marseille, France.
Genomic reconstruction of an azole-resistant Candida parapsilosis outbreak and the creation of a multi-locus sequence typing scheme: a retrospective observational and genomic epidemiology study.
Lancet Microbe
January 2025
Institute of Microbiology Friedrich Schiller University Jena, Jena, Germany; Cluster of Excellence Balance of the Microverse Friedrich Schiller University Jena, Jena, Germany. Electronic address:
Article Synopsis
- Fluconazole-resistant Candida parapsilosis is a growing concern in healthcare settings, leading to outbreaks similar to those caused by Candida auris, with a notable outbreak documented in Berlin from late 2018 through 2022.
- A retrospective study employed whole-genome sequencing (WGS) to analyze samples from various healthcare facilities to track the spread and resistance patterns of this pathogen.
- The research aimed to create a reliable multi-locus sequence typing (MLST) system to better understand and monitor the outbreak, using patient records and genomic data to analyze transmission dynamics.
Blood transcriptomic analyses do not support SARS-CoV-2 persistence in patients with post-COVID-19 condition with chronic fatigue syndrome.
Lancet Microbe
October 2024
Mike Petryk School of Dentistry, Division of Foundational Sciences University of Alberta, Edmonton, AB T6G 2E1, Canada; Li Ka Shing Institute of Virology University of Alberta, Edmonton, AB T6G 2E1, Canada; Women and Children Health Research Institute University of Alberta, Edmonton, AB T6G 2E1, Canada; Cancer Research Institute of Northern Alberta University of Alberta, Edmonton, AB T6G 2E1, Canada; Glycomics Institute of Alberta, Faculty of Medicine and Dentistry University of Alberta, Edmonton, AB T6G 2E1, Canada. Electronic address:
Comparative effectiveness of cognitive behavioural therapy, modafinil, and their combination for treating fatigue in multiple sclerosis (COMBO-MS): a randomised, statistician-blinded, parallel-arm trial.
Lancet Neurol
November 2024
Department of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, MI, USA.
Background: Fatigue is one of the most disabling symptoms reported by people with multiple sclerosis. Although behavioural and pharmacological interventions might be partly beneficial, their combined effects have not been evaluated for multiple sclerosis fatigue, or examined with sufficient consideration of characteristics that might affect treatment response. In this comparative effectiveness research trial, we compared the effectiveness of cognitive behavioural therapy (CBT), modafinil, and their combination for treating multiple sclerosis fatigue.
View Article and Find Full Text PDFImpact of COVID-19 on total excess mortality and geographic disparities in Europe, 2020-2023: a spatio-temporal analysis.
Lancet Reg Health Eur
September 2024
Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Via Commenda 9, Milan 20122, Italy.
Background: COVID-19 dramatically reshaped mortality across Europe. This study aimed to assess its impact on total mortality in European countries taking into consideration the relationship with selected country-level socioeconomic indicators, non-pharmaceutical interventions, and vaccine uptake.
Methods: We obtained weekly mortality data from 2010 to 2023 from the Short-term Mortality Fluctuations data series, the annual population data from the United Nations archives, selected sociodemographic and economic indicators from the World Bank's database, the stringency index and the percentage of the population fully vaccinated from Our World in Data.
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