The incidence of Autism Spectrum Disorder (ASD) among children, attributed to genetics and environmental factors, has been increasing daily. ASD is a non-curable neurodevelopmental disorder that affects children's communication, behavior, social interaction, and learning skills. While machine learning has been employed for ASD detection in children, existing ASD frameworks offer limited services to monitor and improve the health of ASD patients. This paper presents a complex and efficient ASD framework with comprehensive services to enhance the results of existing ASD frameworks. Our proposed approach is the Federated Learning-enabled CNN-LSTM (FCNN-LSTM) scheme, designed for ASD detection in children using multimodal datasets. The ASD framework is built in a distributed computing environment where different ASD laboratories are connected to the central hospital. The FCNN-LSTM scheme enables local laboratories to train and validate different datasets, including Ages and Stages Questionnaires (ASQ), Facial Communication and Symbolic Behavior Scales (CSBS) Dataset, Parents Evaluate Developmental Status (PEDS), Modified Checklist for Autism in Toddlers (M-CHAT), and Screening Tool for Autism in Toddlers and Children (STAT) datasets, on different computing laboratories. To ensure the security of patient data, we have implemented a security mechanism based on advanced standard encryption (AES) within the federated learning environment. This mechanism allows all laboratories to offload and download data securely. We integrate all trained datasets into the aggregated nodes and make the final decision for ASD patients based on the decision process tree. Additionally, we have designed various Internet of Things (IoT) applications to improve the efficiency of ASD patients and achieve more optimal learning results. Simulation results demonstrate that our proposed framework achieves an ASD detection accuracy of approximately 99% compared to all existing ASD frameworks.
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http://dx.doi.org/10.1016/j.compbiomed.2023.107539 | DOI Listing |
Psychol Trauma
January 2025
Paul Baerwald School of Social Work and Social Welfare, Hebrew University of Jerusalem.
Objective: The Adult Scale/National Stressful Events Survey Short Scale (NSESSS) is an emerging brief screening measure for the severity of Acute Stress Symptoms based on the of acute stress disorder (ASD). Scant information is known about the NSESSS's psychometric properties among different cultures or populations exposed to an ongoing trauma and displacement. Therefore, the present study aimed to (a) assess for the first time the psychometric properties and construct validity of the Hebrew version of NSESSS in an internally displaced population following the massacre in Israel on October 7, 2023; and (b) assess the possible risk and protective predictors of ASD according to sociodemographic characteristics, types of trauma exposure, absence of basic needs, and social support.
View Article and Find Full Text PDFHum Genet
January 2025
Department of Biomedical Sciences, University of Padova, Padova, Italy.
The Genetics of Neurodevelopmental Disorders Lab in Padua provided a new intellectual disability (ID) Panel challenge for computational methods to predict patient phenotypes and their causal variants in the context of the Critical Assessment of the Genome Interpretation, 6th edition (CAGI6). Eight research teams submitted a total of 30 models to predict phenotypes based on the sequences of 74 genes (VCF format) in 415 pediatric patients affected by Neurodevelopmental Disorders (NDDs). NDDs are clinically and genetically heterogeneous conditions, with onset in infant age.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Artificial Intelligence in Biomedical Imaging Laboratory (AIBIL), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Background: Brain morphology changes due to both natural aging and various pathological conditions. We used magnetic resonance imaging (MRI) and artificial intelligence (AI) to derive three brain age gaps (Wen et al., 2023b) [gray matter (GM), white matter (WM), and functional connectivity (FC)-BAG] for brain aging and 9 dimensional neuroimaging endophenotypes (Wen et al.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Faculty of Medicine, Arish University, Arish, North Sinai, Egypt.
Background: Lingual taste cells (LTCs) are taste buds' sensory cells that modulate gustation. This study's aim is to assess whether it can be successfully implanted in hippocampus, modulating learning and memory deficits observed in Alzheimer's Dementia (AD).
Methods: Retrospective trials on rodents i.
Alzheimers Dement
December 2024
Artificial Intelligence in Biomedical Imaging Laboratory (AIBIL), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Background: Brain morphology changes due to both natural aging and various pathological conditions. We used magnetic resonance imaging (MRI) and artificial intelligence (AI) to derive three brain age gaps (Wen et al., 2023b) [gray matter (GM), white matter (WM), and functional connectivity (FC)-BAG] for brain aging and 9 dimensional neuroimaging endophenotypes (Wen et al.
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